Bleeding phenotype of patients with moderate haemophilia A and B assessed by thromboelastometry and thrombin generation

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dc.contributor.author Maseide, Ragnhild J.
dc.contributor.author Berntorp, Erik
dc.contributor.author Nummi, Vuokko
dc.contributor.author Lassila, Riitta
dc.contributor.author Tjonnfjord, Geir E.
dc.contributor.author Holme, Pal A.
dc.date.accessioned 2022-02-16T16:29:01Z
dc.date.available 2022-02-16T16:29:01Z
dc.date.issued 2021-09
dc.identifier.citation Maseide , R J , Berntorp , E , Nummi , V , Lassila , R , Tjonnfjord , G E & Holme , P A 2021 , ' Bleeding phenotype of patients with moderate haemophilia A and B assessed by thromboelastometry and thrombin generation ' , Haemophilia , vol. 27 , no. 5 , pp. 793-801 . https://doi.org/10.1111/hae.14355
dc.identifier.other PURE: 167144729
dc.identifier.other PURE UUID: 375cb1e9-7fac-45fe-8b13-789b229537c4
dc.identifier.other WOS: 000659198800001
dc.identifier.uri http://hdl.handle.net/10138/340475
dc.description.abstract Introduction Predicting the bleeding phenotype is crucial for the management of patients with moderate haemophilia. Global coagulation assays evaluate haemostasis more comprehensively than conventional methods. Aim To explore global coagulation assays and the bleeding phenotype of patients with moderate haemophilia A (MHA) and B (MHB). Methods The MoHem study is a cross-sectional, multicentre study covering Nordic patients with MHA and MHB. Thromboelastometry in whole blood and thrombin generation (TG) in platelet-poor plasma (1, 2.5 and 5 pM tissue factor (TF)) were compared with joint health (Haemophilia Joint Health Score (HJHS)) and treatment modality. Results We report on 61 patients from Oslo and Helsinki: 24 MHA and 37 MHB. By TG (2.5 pM TF), patients who had been without replacement therapy during the previous 12 months depicted higher endogenous thrombin potential (P = .03). In contrast, those who had low ETP (< median) captured higher HJHS (P = .02). Patients who had undergone orthopaedic surgery generated least thrombin (P = .02). By thromboelastometry, those without the need of factor consumption had short clotting times, and quick times to maximum velocity (< median values) (P = .03). Factor VIII/factor IX activity (FVIII/FIX:C) did not align with the bleeding phenotype, but FIX:C Conclusion TG differentiated patients with moderate haemophilia according to HJHS, annual factor consumption, and whether orthopaedic surgery had been performed. Thromboelastometry differentiated according to factor consumption only. Global coagulation assays may assist predicting the bleeding phenotype in moderate haemophilia. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Haemophilia
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject bleeding phenotype
dc.subject joint score
dc.subject moderate haemophilia A
dc.subject moderate haemophilia B
dc.subject thrombin generation
dc.subject thromboelastometry
dc.subject CALIBRATED AUTOMATED THROMBOGRAPHY
dc.subject GLOBAL COAGULATION ASSAYS
dc.subject ONE-STAGE
dc.subject CONTACT FACTOR
dc.subject COMMUNICATION
dc.subject SSC
dc.subject DIAGNOSIS
dc.subject PROPOSAL
dc.subject SCORE
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Bleeding phenotype of patients with moderate haemophilia A and B assessed by thromboelastometry and thrombin generation en
dc.type Article
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Clinicum
dc.contributor.organization Research Program in Systems Oncology
dc.contributor.organization Department of Oncology
dc.contributor.organization Hematologian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/hae.14355
dc.relation.issn 1351-8216
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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