The organization of functional neurocognitive networks in focal epilepsy correlates with domain-specific cognitive performance

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Hatlestad-Hall , C , Bruna , R , Erichsen , A , Andersson , V , Syvertsen , M R , Skogan , A H , Renvall , H , Marra , C , Maestu , F , Heuser , K , Tauboll , E , Solbakk , A-K & Haraldsen , I H 2021 , ' The organization of functional neurocognitive networks in focal epilepsy correlates with domain-specific cognitive performance ' , Journal of Neuroscience Research , vol. 99 , no. 10 , pp. 2669-2687 . https://doi.org/10.1002/jnr.24896

Title: The organization of functional neurocognitive networks in focal epilepsy correlates with domain-specific cognitive performance
Author: Hatlestad-Hall, Christoffer; Bruna, Ricardo; Erichsen, Aksel; Andersson, Vebjorn; Syvertsen, Marte Roa; Skogan, Annette Holth; Renvall, Hanna; Marra, Camillo; Maestu, Fernando; Heuser, Kjell; Tauboll, Erik; Solbakk, Anne-Kristin; Haraldsen, Ira H.
Contributor organization: HUS Neurocenter
HUS Medical Imaging Center
BioMag Laboratory
HUS Diagnostic Center
University of Helsinki
Date: 2021-10
Language: eng
Number of pages: 19
Belongs to series: Journal of Neuroscience Research
ISSN: 0360-4012
DOI: https://doi.org/10.1002/jnr.24896
URI: http://hdl.handle.net/10138/340483
Abstract: Understanding and diagnosing cognitive impairment in epilepsy remains a prominent challenge. New etiological models suggest that cognitive difficulties might not be directly linked to seizure activity, but are rather a manifestation of a broader brain pathology. Consequently, treating seizures is not sufficient to alleviate cognitive symptoms, highlighting the need for novel diagnostic tools. Here, we investigated whether the organization of three intrinsic, resting-state functional connectivity networks was correlated with domain-specific cognitive test performance. Using individualized EEG source reconstruction and graph theory, we examined the association between network small worldness and cognitive test performance in 23 patients with focal epilepsy and 17 healthy controls, who underwent a series of standardized pencil-and-paper and digital cognitive tests. We observed that the specific networks robustly correlated with test performance in distinct cognitive domains. Specifically, correlations were evident between the default mode network and memory in patients, the central-executive network and executive functioning in controls, and the salience network and social cognition in both groups. Interestingly, the correlations were evident in both groups, but in different domains, suggesting an alteration in these functional neurocognitive networks in focal epilepsy. The present findings highlight the potential clinical relevance of functional brain network dysfunction in cognitive impairment.
Subject: cognitive impairment
focal epilepsy
functional connectivity
graph theory
neurocognitive networks
RRID
SCR_002510
SCR_003550
SCR_004841
SCR_004849
SCR_007037
SCR_007292
SCR_013202
source EEG
TEMPORAL-LOBE EPILEPSY
DEFAULT MODE NETWORK
RESTING-STATE FMRI
SCALE BRAIN NETWORKS
NEUROBEHAVIORAL COMORBIDITIES
CONNECTIVITY NETWORKS
SALIENCE NETWORK
ADULT EPILEPSY
EEG
MEG
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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