Association of different enteroviruses with atopy and allergic diseases in early childhood

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Palmu , T , Lehtonen , J , Korhonen , L , Virtanen , S M , Niemelä , O , Toppari , J , Ilonen , J , Veijola , R , Knip , M , Laitinen , O H , Lönnrot , M & Hyöty , H 2021 , ' Association of different enteroviruses with atopy and allergic diseases in early childhood ' , Pediatric Allergy and Immunology , vol. 32 , no. 8 , pp. 1629-1636 . https://doi.org/10.1111/pai.13577

Title: Association of different enteroviruses with atopy and allergic diseases in early childhood
Author: Palmu, Tiina; Lehtonen, Jussi; Korhonen, Laura; Virtanen, Suvi M.; Niemelä, Onni; Toppari, Jorma; Ilonen, Jorma; Veijola, Riitta; Knip, Mikael; Laitinen, Olli H.; Lönnrot, Maria; Hyöty, Heikki
Contributor organization: HUS Children and Adolescents
Children's Hospital
Research Programs Unit
CAMM - Research Program for Clinical and Molecular Metabolism
Date: 2021-11
Language: eng
Number of pages: 8
Belongs to series: Pediatric Allergy and Immunology
ISSN: 0905-6157
DOI: https://doi.org/10.1111/pai.13577
URI: http://hdl.handle.net/10138/340501
Abstract: Background Enterovirus (EV) infections, being among the most prevalent viruses worldwide, have been associated with reduced risk of allergic diseases. We sought to determine the association between EVs and allergic sensitization and disease in early childhood. Methods The study was carried out in a nested case-control setting within a prospective birth cohort in Finland. We included 138 case children who had specific IgE (s-IgE) sensitization at the age of 5 years and 138 control children without s-IgE sensitization. Allergic disease was recorded at study visits and identified with the ISAAC questionnaire. We screened for the presence of serotype-specific antibodies against 41 EVs at 1-5 years of age and assessed their association with allergic sensitization and disease. Results The overall number of EV infections did not differ between s-IgE-sensitized children and non-sensitized control children. However, there was a tendency of case children with an allergic disease having less EV infections than their controls. This observation was statistically significant for species A EVs in case children with atopic dermatitis vs. control children: OR 0.6 (95% CI 0.36-0.99), p = .048. Conclusion This study supports the evidence that EV exposure and development of allergic disease are inversely associated. Interestingly, the inverse association was not observed for bare atopic IgE sensitization, but for IgE sensitization coupled with clinical atopic disease. This suggests that environmental factors influencing IgE sensitization may differ from those influencing progression to clinical allergic disease.
Subject: allergic rhinitis
allergy
asthma
atopic dermatitis
atopic sensitization
children
enterovirus
COXSACKIEVIRUS B1
SENSITIZATION
IGE
INFECTIONS
FOODBORNE
CHILDREN
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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