Mendelian randomisation study of smoking exposure in relation to breast cancer risk

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NBCS Collaborators , ABCTB Investigators , kConFab Investigators , Park , H A , Neumeyer , S , Michailidou , K , Muranen , T A & Nevanlinna , H 2021 , ' Mendelian randomisation study of smoking exposure in relation to breast cancer risk ' , British Journal of Cancer , vol. 125 , no. 8 , pp. 1135-1145 .

Title: Mendelian randomisation study of smoking exposure in relation to breast cancer risk
Author: NBCS Collaborators; ABCTB Investigators; kConFab Investigators; Park, Hanla A.; Neumeyer, Sonja; Michailidou, Kyriaki; Muranen, Taru A.; Nevanlinna, Heli
Contributor organization: HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
Date: 2021-10-12
Language: eng
Number of pages: 11
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
Abstract: Background Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 x 10(-2)), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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