Mauramo , M , Mauramo , E , Sorsa , T , Tervahartiala , T , Räisänen , I T & Waltimo , T 2021 , ' Human leukocyte antigens are associated with salivary level of active MMP-8 ' , Clinical and Experimental Dental Research , vol. 7 , no. 5 , pp. 833-839 . https://doi.org/10.1002/cre2.419
Title: | Human leukocyte antigens are associated with salivary level of active MMP-8 |
Author: | Mauramo, Matti; Mauramo, Elina; Sorsa, Timo; Tervahartiala, Taina; Räisänen, Ismo T.; Waltimo, Tuomas |
Contributor organization: | Department of Pathology HUSLAB HUS Head and Neck Center Clinicum Department of Public Health Department of Oral and Maxillofacial Diseases |
Date: | 2021-10 |
Language: | eng |
Number of pages: | 7 |
Belongs to series: | Clinical and Experimental Dental Research |
ISSN: | 2057-4347 |
DOI: | https://doi.org/10.1002/cre2.419 |
URI: | http://hdl.handle.net/10138/340526 |
Abstract: | Objectives: This case control study examined the associations of HLA antigens and periodontitis with the salivary level of active MMP-8 (aMMP-8). Materials and Methods: A total of 202 subjects, registered as Swiss bone marrow donors, participated in the study. HLA-A, -B, and -C types were determined by serology or PCR. Saliva samples were collected from subjects, followed by a periodontal examination. The salivary level of aMMP-8 was determined with immunofluorometric assay. Results: The mean salivary level of aMMP-8 was directly comparable to the grade of periodontitis and increased from healthy to mild/moderate to severe (125.0 +/- 132.1, 200.6 +/- 170.2, 290.1 +/- 202.3 ng/ml; p < 0.001 between each group, respectively). The only association between the HLA types and the salivary level of aMMP-8 was observed in subjects with HLA-A11. Subjects with healthy periodontium and HLA-A11 had a lower level of aMMP-8 (49.2 +/- 32.5 ng/ml) compared with subjects without HLA-A11 (123.6 +/- 119.2; p = 0.048). Among subjects with periodontitis, a higher level of aMMP-8 (394.2 +/- 255.6 ng/ml) was observed in subjects with HLA-A11 compared with subjects without HLA-A11 (201.1 +/- 146.1 ng/ml; p < 0.002). This finding was statistically significant also after adjusting for sex, age, smoking, tooth brushing and the number of medications (p < 0.05). Conclusions: HLA-A11 is associated with the salivary level of aMMP-8 which contributes to the subject's immune and inflammatory response in periodontium. |
Subject: |
human leukocyte antigen
mmp8 periodontitis salivary MATRIX METALLOPROTEINASE-8 RHEUMATOID-ARTHRITIS HLA-A PERIODONTITIS INFLAMMATION PREVALENCE BIOMARKERS HIGHLANDS SMOKING UPDATE 313 Dentistry |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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