Human leukocyte antigens are associated with salivary level of active MMP-8

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http://hdl.handle.net/10138/340526

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Mauramo , M , Mauramo , E , Sorsa , T , Tervahartiala , T , Räisänen , I T & Waltimo , T 2021 , ' Human leukocyte antigens are associated with salivary level of active MMP-8 ' , Clinical and Experimental Dental Research , vol. 7 , no. 5 , pp. 833-839 . https://doi.org/10.1002/cre2.419

Titel: Human leukocyte antigens are associated with salivary level of active MMP-8
Författare: Mauramo, Matti; Mauramo, Elina; Sorsa, Timo; Tervahartiala, Taina; Räisänen, Ismo T.; Waltimo, Tuomas
Upphovmannens organisation: Department of Pathology
HUSLAB
HUS Head and Neck Center
Clinicum
Department of Public Health
Department of Oral and Maxillofacial Diseases
Datum: 2021-10
Språk: eng
Sidantal: 7
Tillhör serie: Clinical and Experimental Dental Research
ISSN: 2057-4347
DOI: https://doi.org/10.1002/cre2.419
Permanenta länken (URI): http://hdl.handle.net/10138/340526
Abstrakt: Objectives: This case control study examined the associations of HLA antigens and periodontitis with the salivary level of active MMP-8 (aMMP-8). Materials and Methods: A total of 202 subjects, registered as Swiss bone marrow donors, participated in the study. HLA-A, -B, and -C types were determined by serology or PCR. Saliva samples were collected from subjects, followed by a periodontal examination. The salivary level of aMMP-8 was determined with immunofluorometric assay. Results: The mean salivary level of aMMP-8 was directly comparable to the grade of periodontitis and increased from healthy to mild/moderate to severe (125.0 +/- 132.1, 200.6 +/- 170.2, 290.1 +/- 202.3 ng/ml; p < 0.001 between each group, respectively). The only association between the HLA types and the salivary level of aMMP-8 was observed in subjects with HLA-A11. Subjects with healthy periodontium and HLA-A11 had a lower level of aMMP-8 (49.2 +/- 32.5 ng/ml) compared with subjects without HLA-A11 (123.6 +/- 119.2; p = 0.048). Among subjects with periodontitis, a higher level of aMMP-8 (394.2 +/- 255.6 ng/ml) was observed in subjects with HLA-A11 compared with subjects without HLA-A11 (201.1 +/- 146.1 ng/ml; p < 0.002). This finding was statistically significant also after adjusting for sex, age, smoking, tooth brushing and the number of medications (p < 0.05). Conclusions: HLA-A11 is associated with the salivary level of aMMP-8 which contributes to the subject's immune and inflammatory response in periodontium.
Subject: human leukocyte antigen
mmp8
periodontitis
salivary
MATRIX METALLOPROTEINASE-8
RHEUMATOID-ARTHRITIS
HLA-A
PERIODONTITIS
INFLAMMATION
PREVALENCE
BIOMARKERS
HIGHLANDS
SMOKING
UPDATE
313 Dentistry
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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