Human leukocyte antigens are associated with salivary level of active MMP-8

Show simple item record

dc.contributor.author Mauramo, Matti
dc.contributor.author Mauramo, Elina
dc.contributor.author Sorsa, Timo
dc.contributor.author Tervahartiala, Taina
dc.contributor.author Räisänen, Ismo T.
dc.contributor.author Waltimo, Tuomas
dc.date.accessioned 2022-02-17T08:37:01Z
dc.date.available 2022-02-17T08:37:01Z
dc.date.issued 2021-10
dc.identifier.citation Mauramo , M , Mauramo , E , Sorsa , T , Tervahartiala , T , Räisänen , I T & Waltimo , T 2021 , ' Human leukocyte antigens are associated with salivary level of active MMP-8 ' , Clinical and Experimental Dental Research , vol. 7 , no. 5 , pp. 833-839 . https://doi.org/10.1002/cre2.419
dc.identifier.other PURE: 169501173
dc.identifier.other PURE UUID: 5f512305-3681-48c9-9e6d-f45f8022d5cb
dc.identifier.other WOS: 000689702100001
dc.identifier.other ORCID: /0000-0001-5821-5299/work/108467087
dc.identifier.uri http://hdl.handle.net/10138/340526
dc.description.abstract Objectives: This case control study examined the associations of HLA antigens and periodontitis with the salivary level of active MMP-8 (aMMP-8). Materials and Methods: A total of 202 subjects, registered as Swiss bone marrow donors, participated in the study. HLA-A, -B, and -C types were determined by serology or PCR. Saliva samples were collected from subjects, followed by a periodontal examination. The salivary level of aMMP-8 was determined with immunofluorometric assay. Results: The mean salivary level of aMMP-8 was directly comparable to the grade of periodontitis and increased from healthy to mild/moderate to severe (125.0 +/- 132.1, 200.6 +/- 170.2, 290.1 +/- 202.3 ng/ml; p < 0.001 between each group, respectively). The only association between the HLA types and the salivary level of aMMP-8 was observed in subjects with HLA-A11. Subjects with healthy periodontium and HLA-A11 had a lower level of aMMP-8 (49.2 +/- 32.5 ng/ml) compared with subjects without HLA-A11 (123.6 +/- 119.2; p = 0.048). Among subjects with periodontitis, a higher level of aMMP-8 (394.2 +/- 255.6 ng/ml) was observed in subjects with HLA-A11 compared with subjects without HLA-A11 (201.1 +/- 146.1 ng/ml; p < 0.002). This finding was statistically significant also after adjusting for sex, age, smoking, tooth brushing and the number of medications (p < 0.05). Conclusions: HLA-A11 is associated with the salivary level of aMMP-8 which contributes to the subject's immune and inflammatory response in periodontium. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Clinical and Experimental Dental Research
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject human leukocyte antigen
dc.subject mmp8
dc.subject periodontitis
dc.subject salivary
dc.subject MATRIX METALLOPROTEINASE-8
dc.subject RHEUMATOID-ARTHRITIS
dc.subject HLA-A
dc.subject PERIODONTITIS
dc.subject INFLAMMATION
dc.subject PREVALENCE
dc.subject BIOMARKERS
dc.subject HIGHLANDS
dc.subject SMOKING
dc.subject UPDATE
dc.subject 313 Dentistry
dc.title Human leukocyte antigens are associated with salivary level of active MMP-8 en
dc.type Article
dc.contributor.organization Department of Pathology
dc.contributor.organization HUSLAB
dc.contributor.organization HUS Head and Neck Center
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization Department of Oral and Maxillofacial Diseases
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1002/cre2.419
dc.relation.issn 2057-4347
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Clinical_Exp_De ... _level_of_active_MMP_8.pdf 881.3Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record