Waist and hip circumference are independently associated with the risk of liver disease in population-based studies

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Danielsson , O A , Nissinen , M , Jula , A , Salomaa , V , Männistö , S , Lundqvist , A , Perola , M & Åberg , F 2021 , ' Waist and hip circumference are independently associated with the risk of liver disease in population-based studies ' , Liver International , vol. 41 , no. 12 , pp. 2903-2913 . https://doi.org/10.1111/liv.15053

Title: Waist and hip circumference are independently associated with the risk of liver disease in population-based studies
Author: Danielsson, Oscar A; Nissinen, Markku; Jula, Antti; Salomaa, Veikko; Männistö, Satu; Lundqvist, Annamari; Perola, Markus; Åberg, Fredrik
Contributor organization: HUS Abdominal Center
Gastroenterologian yksikkö
Clinicum
IV kirurgian klinikka
Date: 2021-12
Language: eng
Number of pages: 11
Belongs to series: Liver International
ISSN: 1478-3223
DOI: https://doi.org/10.1111/liv.15053
URI: http://hdl.handle.net/10138/340529
Abstract: Background & Aims While several anthropometric measures predict liver disease, the waist-hip ratio (WHR) has shown superiority in previous studies. We analysed independent and joint associations of waist circumference (WC) and hip circumference (HC) with liver disease and liver-related risk factors. Methods Cross-sectional study (n = 6619) and longitudinal cohort (n = 40 923) comprised individuals from Health 2000 and FINRISK 1992-2012 studies. Prevalent and viral liver diseases were excluded. Longitudinal cohort was linked with national healthcare registers for severe incident liver disease. Linear regression and Cox proportional hazards models were used to analyse anthropometric, lifestyle, metabolic and bioimpedance-related parameters; liver enzymes; and 59 liver-related genetic risk variants. Results WC and HC showed independent and opposite associations with both liver enzymes and incident liver disease among men (HR for liver disease: WC, 1.07, 95% CI 1.03-1.11; HC, 0.96, 95% CI 0.92-0.99; P-range .04 to
Subject: BODY-COMPOSITION
CARDIOVASCULAR RISK
FATTY LIVER
INSULIN-RESISTANCE
NORMAL-WEIGHT
OBESITY
PREDICTS DEVELOPMENT
RATIO
SKELETAL-MUSCLE MASS
WHOLE-BODY
anthropometric measures
body mass index
fat
sarcopenia
waist-hip ratio
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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