Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors : a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT

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Masouridi-Levrat , S , Olavarria , E , Iacobelli , S , Aljurf , M , Morozova , E , Niittyvuopio , R , Sengeloev , H , Remenyi , P , Helbig , G , Browne , P , Ganser , A , Nagler , A , Snowden , J A , Robin , M , Passweg , J , Van Gorkom , G , Wallet , H L , Hoek , J , Blok , H-J , De Witte , T , Kroeger , N , Hayden , P , Chalandon , Y & Agha , I Y 2022 , ' Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors : a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT ' , Bone Marrow Transplantation , vol. 57 , no. 1 , pp. 23-30 . https://doi.org/10.1038/s41409-021-01472-x

Title: Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors : a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT
Author: Masouridi-Levrat, Stavroula; Olavarria, Eduardo; Iacobelli, Simona; Aljurf, Mahmoud; Morozova, Elena; Niittyvuopio, Riitta; Sengeloev, Henrik; Remenyi, Peter; Helbig, Grzegorz; Browne, Paul; Ganser, Arnold; Nagler, Arnon; Snowden, John A.; Robin, Marie; Passweg, Jakob; Van Gorkom, Gwendolyn; Wallet, Helene Labussiere; Hoek, Jennifer; Blok, Henric-Jan; De Witte, Theo; Kroeger, Nicolaus; Hayden, Patrick; Chalandon, Yves; Agha, Ibrahim Yakoub
Contributor organization: HUS Comprehensive Cancer Center
Hematologian yksikkö
Department of Oncology
Date: 2022-01
Language: eng
Number of pages: 8
Belongs to series: Bone Marrow Transplantation
ISSN: 0268-3369
DOI: https://doi.org/10.1038/s41409-021-01472-x
URI: http://hdl.handle.net/10138/340533
Abstract: Allogeneic hematopoietic cell transplantation (allo-HCT) remains a treatment option for patients with chronic myeloid leukemia (CML) who fail to respond to tyrosine kinase inhibitors (TKIs). While imatinib seems to have no adverse impact on outcomes after transplant, little is known on the effects of prior use of second-generation TKI (2GTKI). We present the results of a prospective non-interventional study performed by the EBMT on 383 consecutive CML patients previously treated with dasatinib or nilotinib undergoing allo-HCT from 2009 to 2013. The median age was 45 years (18-68). Disease status at transplant was CP1 in 139 patients (38%), AP or >CP1 in 163 (45%), and BC in 59 (16%). The choice of 2GTKI was: 40% dasatinib, 17% nilotinib, and 43% a sequential treatment of dasatinib and nilotinib with or without bosutinib/ponatinib. With a median follow-up of 37 months (1-77), 8% of patients developed either primary or secondary graft failure, 34% acute and 60% chronic GvHD. There were no differences in post-transplant complications between the three different 2GTKI subgroups. Non-relapse mortality was 18% and 24% at 12 months and at 5 years, respectively. Relapse incidence was 36%, overall survival 56% and relapse-free survival 40% at 5 years. No differences in post-transplant outcomes were found between the three different 2GTKI subgroups. This prospective study demonstrates the feasibility of allo-HCT in patients previously treated with 2GTKI with a post-transplant complications rate comparable to that of TKI-naive or imatinib-treated patients.
Subject: CHRONIC MYELOGENOUS LEUKEMIA
CHRONIC-PHASE
IMATINIB MESYLATE
PROGNOSTIC-FACTORS
ADVANCED DISEASE
FOLLOW-UP
DASATINIB
NILOTINIB
CML
THERAPY
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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