Long-term survival after primary intracerebral hemorrhage : A population-based case-control study spanning a quarter of a century

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http://hdl.handle.net/10138/340541

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Lahti , A-M , Nätynki , M , Huhtakangas , J , Bode , M , Juvela , S , Ohtonen , P & Tetri , S 2021 , ' Long-term survival after primary intracerebral hemorrhage : A population-based case-control study spanning a quarter of a century ' , European Journal of Neurology , vol. 28 , no. 11 , pp. 3663-3669 . https://doi.org/10.1111/ene.14988

Title: Long-term survival after primary intracerebral hemorrhage : A population-based case-control study spanning a quarter of a century
Author: Lahti, Anna-Maija; Nätynki, Mirva; Huhtakangas, Juha; Bode, Michaela; Juvela, Seppo; Ohtonen, Pasi; Tetri, Sami
Contributor organization: HUS Neurocenter
Department of Neurosciences
Clinicum
Date: 2021-11
Language: eng
Number of pages: 7
Belongs to series: European Journal of Neurology
ISSN: 1351-5101
DOI: https://doi.org/10.1111/ene.14988
URI: http://hdl.handle.net/10138/340541
Abstract: Background and purpose The aim of this study was to determine the differences in life expectancy and causes of death after primary intracerebral hemorrhage (ICH) relative to general population controls. Methods In a population-based setting, 963 patients from Northern Ostrobothnia who had their first-ever ICH between 1993 and 2008 were compared with a cohort of 2884 sex- and age-matched controls in terms of dates and causes of death as extracted from the Causes of Death Register kept by Statistics Finland and valid up to the end of 2017. Results Of our 963 patients, 781 died during the follow-up time (mortality 81.1%). Cerebrovascular disease was the most common cause of death for these patients, 37.3% compared with 8.2% amongst the controls. The most common reasons for cerebrovascular mortality in the ICH patients were late sequelae of ICH in 12.8% (controls 0%) and new bleeding in 10.6% (controls 1.0%). The long-term survivors had a smaller ICH volume (median 12 ml) than those patients who died within 3 months (median 39 ml). The mortality rate of ICH patients during a follow-up between 12 and 24 years was still higher than that of their controls (hazard ratio 2.08, 95% confidence interval 1.58-2.74, p < 0.001). Conclusions Very long-term ICH survivors have a constant excess mortality relative to controls even 10 years after the index event. A significantly larger proportion of patients died of cerebrovascular causes and fewer because of cancer relative to the controls.
Subject: adult
case-control study
cerebrovascular diseases
epidemiology
intracerebral hemorrhage
long-term survival
rehabilitation
MORTALITY
DISEASE
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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