LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers

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Sundqvist , B , Sihto , H , von Willebrand , M , Böhling , T & Koljonen , V 2021 , ' LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers ' , Virchows Archiv , vol. 479 , no. 6 , pp. 1197-1207 . https://doi.org/10.1007/s00428-021-03158-7

Title: LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers
Author: Sundqvist, Benjamin; Sihto, Harri; von Willebrand, Maria; Böhling, Tom; Koljonen, Virve
Contributor organization: Department of Pathology
Medicum
University of Helsinki
HUSLAB
Tom Böhling / Principal Investigator
Department of Surgery
HUS Musculoskeletal and Plastic Surgery
Plastiikkakirurgian yksikkö
Date: 2021-12
Language: eng
Number of pages: 11
Belongs to series: Virchows Archiv
ISSN: 0945-6317
DOI: https://doi.org/10.1007/s00428-021-03158-7
URI: http://hdl.handle.net/10138/340546
Abstract: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine malignancy of the skin. The cell of origin of MCC is thus far unknown and proposed cells of origin include Merkel cells, pro-/pre- or pre-B cells, epithelial stem cells, and dermal stem cells. In this study, we aimed to shed further light on the possibility that a subset of MCC tumors arise from epithelial stem cells of the skin by examining the expression of hair follicle and epidermal stem cell markers in MCC and normal human skin. We also aimed to elucidate any correlation between the expression of these markers and tumor Merkel cell polyomavirus (MCPyV) status or other clinicopathological characteristics or patient survival. Expression of CK19, SOX9, LGR5, and LRIG1 in MCC and normal human skin was studied by immunohistochemistry, and the staining patterns or intensities were statistically correlated with patient, tumor, MCPyV, and survival parameters. In a cohort of 137 cases of MCC, we observed dot-like immunoexpression of CK19 in 30 cases (22.1%) and homogeneous expression in 103 cases (75.7%). We also observed positive immunoexpression of SOX9 in 21 cases (15.3%), LGR5 in 118 cases (86.1%), and LRIG1 in 117 cases (86.0%). Immunoexpression of LRIG1 was found to correlate with better overall and MCC-specific survival. We observed frequent immunoexpression of several hair follicle and epidermal stem cell markers in MCC and found LRIG1 to be a positive prognostic marker in MCC.
Subject: Merkel cell carcinoma
Stem cell
Hair follicle
LRIG1
Immunohistochemistry
HUMAN-PAPILLOMAVIRUS STATUS
HAIR FOLLICLE
POLYOMAVIRUS INFECTION
T-ANTIGEN
IN-VIVO
DIFFERENTIATION
HISTOGENESIS
SKIN
ORIGIN
GROWTH
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion
Funder: Suomen tiedeseura
Sarcoma Foundation of America
Grant number:


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