Engineered mesoporous silica reduces long-term blood glucose and HbA1c, and improves metabolic parameters in prediabetics

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Baek , J , Robert-Nicoud , G , Hidalgo , C H , Borg , M L , Iqbal , M N , Berlin , R , Lindgren , M , Waara , E , Udden , A , Pietiläinen , K & Bengtsson , T 2022 , ' Engineered mesoporous silica reduces long-term blood glucose and HbA1c, and improves metabolic parameters in prediabetics ' , Nanomedicine , vol. 17 , no. 1 , pp. 9-22 . https://doi.org/10.2217/nnm-2021-0235

Title: Engineered mesoporous silica reduces long-term blood glucose and HbA1c, and improves metabolic parameters in prediabetics
Author: Baek, Jeanha; Robert-Nicoud, Ghislaine; Hidalgo, Carmen Herrera; Borg, Melissa L.; Iqbal, Muhammad N.; Berlin, Roger; Lindgren, Maria; Waara, Erik; Udden, Anna; Pietiläinen, Kirsi; Bengtsson, Tore
Contributor organization: HUS Abdominal Center
Department of Medicine
Clinicum
University of Helsinki
CAMM - Research Program for Clinical and Molecular Metabolism
Date: 2022-01
Language: eng
Number of pages: 14
Belongs to series: Nanomedicine
ISSN: 1743-5889
DOI: https://doi.org/10.2217/nnm-2021-0235
URI: http://hdl.handle.net/10138/340547
Abstract: Aim: To investigate the effect of oral consumption of engineered mesoporous silica particles, SiPore15 (R), on long-term blood glucose levels and other metabolic parameters in individuals with prediabetes and newly diagnosed Type 2 diabetes. Method: An open-label, single-arm, multicenter trial was conducted in which SiPore15 was consumed three times daily for 12 weeks. Hemoglobin A1c (HbA1c, primary end point) and an array of metabolic parameters were measured at baseline and throughout the trial. Result: SiPore15 treatment significantly reduced HbA1c by a clinically meaningful degree and improved several disease-associated parameters with minimal side effects. Conclusion: The results from this study demonstrate the potential use of SiPore15 as a treatment for prediabetes that may also delay or prevent the onset of Type 2 diabetes.
Subject: diabetes prevention
HbA1c
medical device
mesoporous silica particles
prediabetes
Type 2 diabetes
SAGITTAL ABDOMINAL DIAMETER
LIFE-STYLE INTERVENTION
INSULIN-RESISTANCE
BODY-FAT
METAANALYSIS
RISK
318 Medical biotechnology
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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