Profile of minor neurological findings after perinatal asphyxia

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Kivi , A , Metsäranta , M , Toiviainen-Salo , S , Vanhatalo , S & Haataja , L 2022 , ' Profile of minor neurological findings after perinatal asphyxia ' , Acta Paediatrica , vol. 111 , no. 2 , pp. 291-299 .

Titel: Profile of minor neurological findings after perinatal asphyxia
Författare: Kivi, Anna; Metsäranta, Marjo; Toiviainen-Salo, Sanna; Vanhatalo, Sampsa; Haataja, Leena
Upphovmannens organisation: HUS Children and Adolescents
Children's Hospital
HUS Medical Imaging Center
University of Helsinki
HUS Diagnostic Center
Kliinisen neurofysiologian yksikkö
Department of Neurosciences
Neuroscience Center
Helsinki Institute of Life Science HiLIFE
Lastenneurologian yksikkö
Datum: 2022-02
Språk: eng
Sidantal: 9
Tillhör serie: Acta Paediatrica
ISSN: 0803-5253
Permanenta länken (URI):
Abstrakt: Aim To characterise the spectrum of findings in sequential neurological examinations, general movements (GM) assessment and magnetic resonance imaging (MRI) of infants with perinatal asphyxia. Methods The prospective cohort study of term infants with perinatal asphyxia treated at Helsinki University Hospital's neonatal units in 2016-2020 used Hammersmith Neonatal Neurological Examination (HNNE) and brain MRI at 2 weeks and Hammersmith Infant Neurological Examination (HINE) and GM assessment at 3 months of age. Results Analysis included 50 infants: 33 displaying perinatal asphyxia without hypoxic-ischaemic encephalopathy (HIE), seven with HIE1 and 10 with HIE2. Of the infants with atypical HNNE findings, 24/25 perinatal asphyxia without HIE cases, 5/6 HIE1 cases and all 10 HIE2 cases showed atypical findings in the HINE. The HINE identified atypical spontaneous movements significantly more often in infants with white matter T2 hyperintensity. Conclusion In this cohort, most infants with perinatal asphyxia, with or without HIE, presented atypical neurological findings in sequential examinations. The profile of neurological findings for children with perinatal asphyxia without HIE resembled that of children with HIE. White matter T2 hyperintensity was associated with atypical spontaneous movements in the HINE and was a frequent MRI finding also in perinatal asphyxia without HIE.
Subject: general movements
hypoxic-ischaemic encephalopathy
infant neurological examination
minor neurological finding
perinatal asphyxia
3123 Gynaecology and paediatrics
3124 Neurology and psychiatry
Referentgranskad: Ja
Licens: cc_by_nc
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion

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