Profile of minor neurological findings after perinatal asphyxia

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dc.contributor.author Kivi, Anna
dc.contributor.author Metsäranta, Marjo
dc.contributor.author Toiviainen-Salo, Sanna
dc.contributor.author Vanhatalo, Sampsa
dc.contributor.author Haataja, Leena
dc.date.accessioned 2022-02-17T11:34:01Z
dc.date.available 2022-02-17T11:34:01Z
dc.date.issued 2022-02
dc.identifier.citation Kivi , A , Metsäranta , M , Toiviainen-Salo , S , Vanhatalo , S & Haataja , L 2022 , ' Profile of minor neurological findings after perinatal asphyxia ' , Acta Paediatrica , vol. 111 , no. 2 , pp. 291-299 . https://doi.org/10.1111/apa.16133
dc.identifier.other PURE: 171076969
dc.identifier.other PURE UUID: ad951931-d698-4caa-b2cf-84e11dec7029
dc.identifier.other WOS: 000719468000001
dc.identifier.other ORCID: /0000-0002-8057-6194/work/108466895
dc.identifier.uri http://hdl.handle.net/10138/340550
dc.description.abstract Aim To characterise the spectrum of findings in sequential neurological examinations, general movements (GM) assessment and magnetic resonance imaging (MRI) of infants with perinatal asphyxia. Methods The prospective cohort study of term infants with perinatal asphyxia treated at Helsinki University Hospital's neonatal units in 2016-2020 used Hammersmith Neonatal Neurological Examination (HNNE) and brain MRI at 2 weeks and Hammersmith Infant Neurological Examination (HINE) and GM assessment at 3 months of age. Results Analysis included 50 infants: 33 displaying perinatal asphyxia without hypoxic-ischaemic encephalopathy (HIE), seven with HIE1 and 10 with HIE2. Of the infants with atypical HNNE findings, 24/25 perinatal asphyxia without HIE cases, 5/6 HIE1 cases and all 10 HIE2 cases showed atypical findings in the HINE. The HINE identified atypical spontaneous movements significantly more often in infants with white matter T2 hyperintensity. Conclusion In this cohort, most infants with perinatal asphyxia, with or without HIE, presented atypical neurological findings in sequential examinations. The profile of neurological findings for children with perinatal asphyxia without HIE resembled that of children with HIE. White matter T2 hyperintensity was associated with atypical spontaneous movements in the HINE and was a frequent MRI finding also in perinatal asphyxia without HIE. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Acta Paediatrica
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject general movements
dc.subject hypoxic-ischaemic encephalopathy
dc.subject infant neurological examination
dc.subject minor neurological finding
dc.subject perinatal asphyxia
dc.subject NEONATAL ENCEPHALOPATHY
dc.subject PRETERM INFANTS
dc.subject AGE
dc.subject HYPOTHERMIA
dc.subject NEUROMOTOR
dc.subject OUTCOMES
dc.subject SCORE
dc.subject 3123 Gynaecology and paediatrics
dc.subject 3124 Neurology and psychiatry
dc.title Profile of minor neurological findings after perinatal asphyxia en
dc.type Article
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Children's Hospital
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Diagnostic Center
dc.contributor.organization Kliinisen neurofysiologian yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Neuroscience Center
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.contributor.organization Lastenneurologian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/apa.16133
dc.relation.issn 0803-5253
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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