Patient-Specific Bioimplants and Reconstruction Plates for Mandibular Defects: Production Workflow and In Vivo Large Animal Model Study

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Dienel , K , Abu-Shahba , A , Kornilov , R , Björkstrand , R , van Bochove , B , Snäll , J , Wilkman , T S E , Mesimäki , K , Meller , A , Linden , J , Lappalainen , A , Partanen , J , Seppänen-Kaijansinkko , R , Seppälä , J & Mannerström , B 2022 , ' Patient-Specific Bioimplants and Reconstruction Plates for Mandibular Defects: Production Workflow and In Vivo Large Animal Model Study ' , Macromolecular Bioscience , vol. 22 , no. 4 , 2100398 . https://doi.org/10.1002/mabi.202100398

Title: Patient-Specific Bioimplants and Reconstruction Plates for Mandibular Defects: Production Workflow and In Vivo Large Animal Model Study
Author: Dienel, Kasper; Abu-Shahba, Ahmed; Kornilov, Roman; Björkstrand, Roy; van Bochove, Bas; Snäll, Johanna; Wilkman, Tommy S E; Mesimäki, Karri; Meller, Anna; Linden, Jere; Lappalainen, Anu; Partanen, Jouni; Seppänen-Kaijansinkko, Riitta; Seppälä, Jukka; Mannerström, Bettina
Contributor organization: Department of Oral and Maxillofacial Diseases
Clinicum
HUS Head and Neck Center
Oral and Maxillofacial Surgery
Suu- ja leukakirurgian yksikkö
Helsinki One Health (HOH)
Helsinki Institute of Life Science HiLIFE, Infra
Laboratory Animal Centre
Veterinary Pathology and Parasitology
Veterinary Biosciences
Departments of Faculty of Veterinary Medicine
Petbone – ortopedia, fysioterapia, kivunlievitys
Medicum
Date: 2022-04
Language: eng
Number of pages: 15
Belongs to series: Macromolecular Bioscience
ISSN: 1616-5187
DOI: https://doi.org/10.1002/mabi.202100398
URI: http://hdl.handle.net/10138/340558
Abstract: A major challenge with extensive craniomaxillofacial bone reconstruction is the limited donor-site availability to reconstruct defects predictably and accurately according to the anatomical shape of the patient. Here, patient-specific composite bioimplants, consisting of cross-linked poly(trimethylene carbonate) (PTMC) networks and beta-tricalcium phosphate (beta-TCP), are tested in vivo in twelve Gottingen minipigs in a large mandibular continuity defect model. The 25 mm defects are supported by patient-specific titanium reconstruction plates and receive either osteoconductive composite bioimplants (PTMC+TCP), neat polymer network bioimplants (PTMC), autologous bone segments (positive control), or are left empty (negative control). Postoperatively, defects treated with bioimplants show evident ossification at 24 weeks. Histopathologic evaluation reveals that neat PTMC bioimplant surfaces are largely covered with fibrous tissue, while in the PTMC+TCP bioimplants, bone attached directly to the implant surface shows good osteoconduction and histological signs of osteoinductivity. However, PTMC+TCP bioimplants are associated with high incidence of necrosis and infection, possibly due to rapid resorption and/or particle size of the used beta-TCP. The study highlights the importance of testing bone regeneration implants in a clinically relevant large animal model and at the in situ reconstruction site, since results on small animal models and studies in nonloadbearing areas do not translate directly.
Subject: additive manufacturing
bone reconstructions
calcium phosphates
continuity defects
Gottingen minipigs
poly(trimethylene carbonate)
BETA-TRICALCIUM PHOSPHATE
POROUS TITANIUM MATERIALS
ENTANGLED WIRE STRUCTURE
CRITICAL SIZE DEFECTS
BONE REGENERATION
SCAFFOLDS
BIOMATERIALS
MINIPIGS
QUALITY
1182 Biochemistry, cell and molecular biology
216 Materials engineering
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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