Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites

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Islam , M M , Hlushchenko , I & Pfisterer , S 2022 , ' Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites ' , Frontiers in Cell and Developmental Biology , vol. 10 , 826379 . https://doi.org/10.3389/fcell.2022.826379

Title: Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites
Author: Islam, Mohammad Majharul; Hlushchenko, Iryna; Pfisterer, Simon
Contributor organization: Department of Anatomy
Medicum
Date: 2022-01-24
Language: eng
Number of pages: 6
Belongs to series: Frontiers in Cell and Developmental Biology
ISSN: 2296-634X
DOI: https://doi.org/10.3389/fcell.2022.826379
URI: http://hdl.handle.net/10138/340559
Abstract: Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membrane contact sites influence endosomal dynamics, plasma membrane lipid composition, and cellular cholesterol distribution. However, if we focus on LDL-related trafficking events we mostly discuss them in an isolated fashion, without cellular context. It is our goal to change this perspective and to highlight that all steps from LDL internalization to receptor recycling are likely associated with dynamic membrane contact sites in which endosomes engage with the endoplasmic reticulum and other organelles.
Subject: BINDING
CHOLESTEROL TRANSPORT
EGRESS
ENDOSOMES
ER CONTACT
INSIGHTS
MODULATES ENDOCYTOSIS
NIR2
PLASMA-MEMBRANE
TRAFFICKING
endosomal degradation
endosomal recycling
hypercholesterolemia
low-density lipoprotein (LDL)
low-density lipoprotein receptor (LDLR)
membrane contact site
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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