Global mortality from dementia : Application of a new method and results from the Global Burden of Disease Study 2019

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GBD 2019 Collaborators , Nichols , E , Abd-Allah , F , Abdoli , A , Kivimäki , M , Meretoja , A & Shiri , R 2021 , ' Global mortality from dementia : Application of a new method and results from the Global Burden of Disease Study 2019 ' , Alzheimer's & Dementia: Translational Research & Clinical Interventions , vol. 7 , no. 1 , 12200 . https://doi.org/10.1002/trc2.12200

Title: Global mortality from dementia : Application of a new method and results from the Global Burden of Disease Study 2019
Author: GBD 2019 Collaborators; Nichols, Emma; Abd-Allah, Foad; Abdoli, Amir; Kivimäki, Mika; Meretoja, Atte; Shiri, Rahman
Contributor organization: Department of Public Health
Clinicum
HUS Neurocenter
Neurologian yksikkö
Date: 2021
Language: eng
Number of pages: 28
Belongs to series: Alzheimer's & Dementia: Translational Research & Clinical Interventions
ISSN: 2352-8737
DOI: https://doi.org/10.1002/trc2.12200
URI: http://hdl.handle.net/10138/340591
Abstract: Introduction Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-to-male ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in all-age mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.
Subject: burden of disease
dementia
global health
mortality
CLINICALLY DIAGNOSED DEMENTIA
MILD COGNITIVE IMPAIRMENT
NURSING-HOME RESIDENTS
ALZHEIMERS-DISEASE
DEATH CERTIFICATES
REPORTING DEMENTIA
ALL-CAUSE
POPULATION
SURVIVAL
PREDICTORS
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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