Three genetic-environmental networks for human personality

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Zwir , I , Del-Val , C , Arnedo , J , Pulkki-Råback , L , Konte , B , Yang , S S , Romero-Zaliz , R , Hintsanen , M , Cloninger , K M , Garcia , D , Svrakic , D M , Lester , N , Rozsa , S , Mesa , A , Lyytikainen , L-P , Giegling , I , Kahonen , M , Martinez , M , Seppala , I , Raitoharju , E , de Erausquin , G A , Mamah , D , Raitakari , O , Rujescu , D , Postolache , T T , Gu , C C , Sung , J , Lehtimäki , T , Keltikangas-Jarvinen , L & Cloninger , C R 2021 , ' Three genetic-environmental networks for human personality ' , Molecular Psychiatry , vol. 26 , no. 8 , pp. 3858-3875 . https://doi.org/10.1038/s41380-019-0579-x

Title: Three genetic-environmental networks for human personality
Author: Zwir, Igor; Del-Val, Coral; Arnedo, Javier; Pulkki-Råback, Laura; Konte, Bettina; Yang, Sarah S.; Romero-Zaliz, Rocio; Hintsanen, Mirka; Cloninger, Kevin M.; Garcia, Danilo; Svrakic, Dragan M.; Lester, Nigel; Rozsa, Sandor; Mesa, Alberto; Lyytikainen, Leo-Pekka; Giegling, Ina; Kahonen, Mika; Martinez, Maribel; Seppala, Ilkka; Raitoharju, Emma; de Erausquin, Gabriel A.; Mamah, Daniel; Raitakari, Olli; Rujescu, Dan; Postolache, Teodor T.; Gu, C. Charles; Sung, Joohon; Lehtimäki, Terho; Keltikangas-Jarvinen, Liisa; Cloninger, C. Robert
Contributor organization: Department of Psychology and Logopedics
Psychosocial factors and health
Medicum
Date: 2021-08
Language: eng
Number of pages: 18
Belongs to series: Molecular Psychiatry
ISSN: 1359-4184
DOI: https://doi.org/10.1038/s41380-019-0579-x
URI: http://hdl.handle.net/10138/340601
Abstract: Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems of learning and memory that regulate (1) associative conditioning, (2) intentionality, and (3) self-awareness. We have uncovered largely disjoint sets of genes regulating these dissociable learning processes in different clusters of people with (1) unregulated temperament profiles (i.e., associatively conditioned habits and emotional reactivity), (2) organized character profiles (i.e., intentional self-control of emotional conflicts and goals), and (3) creative character profiles (i.e., self-aware appraisal of values and theories), respectively. However, little is known about how these temperament and character components of personality are jointly organized and develop in an integrated manner. In three large independent genome-wide association studies from Finland, Germany, and Korea, we used a data-driven machine learning method to uncover joint phenotypic networks of temperament and character and also the genetic networks with which they are associated. We found three clusters of similar numbers of people with distinct combinations of temperament and character profiles. Their associated genetic and environmental networks were largely disjoint, and differentially related to distinct forms of learning and memory. Of the 972 genes that mapped to the three phenotypic networks, 72% were unique to a single network. The findings in the Finnish discovery sample were blindly and independently replicated in samples of Germans and Koreans. We conclude that temperament and character are integrated within three disjoint networks that regulate healthy longevity and dissociable systems of learning and memory by nearly disjoint sets of genetic and environmental influences.
Subject: FUNCTIONAL NEUROANATOMY
CARDIOVASCULAR RISK
EPISODIC MEMORY
AUTOBIOGRAPHICAL MEMORY
REGULATORY NETWORK
BASAL GANGLIA
HEALTHY TWIN
TEMPERAMENT
MODEL
DISSOCIATION
1182 Biochemistry, cell and molecular biology
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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