Three genetic-environmental networks for human personality

Show simple item record

dc.contributor.author Zwir, Igor
dc.contributor.author Del-Val, Coral
dc.contributor.author Arnedo, Javier
dc.contributor.author Pulkki-Råback, Laura
dc.contributor.author Konte, Bettina
dc.contributor.author Yang, Sarah S.
dc.contributor.author Romero-Zaliz, Rocio
dc.contributor.author Hintsanen, Mirka
dc.contributor.author Cloninger, Kevin M.
dc.contributor.author Garcia, Danilo
dc.contributor.author Svrakic, Dragan M.
dc.contributor.author Lester, Nigel
dc.contributor.author Rozsa, Sandor
dc.contributor.author Mesa, Alberto
dc.contributor.author Lyytikainen, Leo-Pekka
dc.contributor.author Giegling, Ina
dc.contributor.author Kahonen, Mika
dc.contributor.author Martinez, Maribel
dc.contributor.author Seppala, Ilkka
dc.contributor.author Raitoharju, Emma
dc.contributor.author de Erausquin, Gabriel A.
dc.contributor.author Mamah, Daniel
dc.contributor.author Raitakari, Olli
dc.contributor.author Rujescu, Dan
dc.contributor.author Postolache, Teodor T.
dc.contributor.author Gu, C. Charles
dc.contributor.author Sung, Joohon
dc.contributor.author Lehtimäki, Terho
dc.contributor.author Keltikangas-Jarvinen, Liisa
dc.contributor.author Cloninger, C. Robert
dc.date.accessioned 2022-02-17T16:18:05Z
dc.date.available 2022-02-17T16:18:05Z
dc.date.issued 2021-08
dc.identifier.citation Zwir , I , Del-Val , C , Arnedo , J , Pulkki-Råback , L , Konte , B , Yang , S S , Romero-Zaliz , R , Hintsanen , M , Cloninger , K M , Garcia , D , Svrakic , D M , Lester , N , Rozsa , S , Mesa , A , Lyytikainen , L-P , Giegling , I , Kahonen , M , Martinez , M , Seppala , I , Raitoharju , E , de Erausquin , G A , Mamah , D , Raitakari , O , Rujescu , D , Postolache , T T , Gu , C C , Sung , J , Lehtimäki , T , Keltikangas-Jarvinen , L & Cloninger , C R 2021 , ' Three genetic-environmental networks for human personality ' , Molecular Psychiatry , vol. 26 , no. 8 , pp. 3858-3875 . https://doi.org/10.1038/s41380-019-0579-x
dc.identifier.other PURE: 174237754
dc.identifier.other PURE UUID: c4868039-86b9-40b3-9f2b-633cc96a88e7
dc.identifier.other WOS: 000731712800018
dc.identifier.other ORCID: /0000-0002-7977-3852/work/108462758
dc.identifier.uri http://hdl.handle.net/10138/340601
dc.description.abstract Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems of learning and memory that regulate (1) associative conditioning, (2) intentionality, and (3) self-awareness. We have uncovered largely disjoint sets of genes regulating these dissociable learning processes in different clusters of people with (1) unregulated temperament profiles (i.e., associatively conditioned habits and emotional reactivity), (2) organized character profiles (i.e., intentional self-control of emotional conflicts and goals), and (3) creative character profiles (i.e., self-aware appraisal of values and theories), respectively. However, little is known about how these temperament and character components of personality are jointly organized and develop in an integrated manner. In three large independent genome-wide association studies from Finland, Germany, and Korea, we used a data-driven machine learning method to uncover joint phenotypic networks of temperament and character and also the genetic networks with which they are associated. We found three clusters of similar numbers of people with distinct combinations of temperament and character profiles. Their associated genetic and environmental networks were largely disjoint, and differentially related to distinct forms of learning and memory. Of the 972 genes that mapped to the three phenotypic networks, 72% were unique to a single network. The findings in the Finnish discovery sample were blindly and independently replicated in samples of Germans and Koreans. We conclude that temperament and character are integrated within three disjoint networks that regulate healthy longevity and dissociable systems of learning and memory by nearly disjoint sets of genetic and environmental influences. en
dc.format.extent 18
dc.language.iso eng
dc.relation.ispartof Molecular Psychiatry
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject FUNCTIONAL NEUROANATOMY
dc.subject CARDIOVASCULAR RISK
dc.subject EPISODIC MEMORY
dc.subject AUTOBIOGRAPHICAL MEMORY
dc.subject REGULATORY NETWORK
dc.subject BASAL GANGLIA
dc.subject HEALTHY TWIN
dc.subject TEMPERAMENT
dc.subject MODEL
dc.subject DISSOCIATION
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Three genetic-environmental networks for human personality en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Psychosocial factors and health
dc.contributor.organization Medicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41380-019-0579-x
dc.relation.issn 1359-4184
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41380_019_0579_x.pdf 3.713Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record