Three genetic-environmental networks for human personality

Show simple item record Zwir, Igor Del-Val, Coral Arnedo, Javier Pulkki-Råback, Laura Konte, Bettina Yang, Sarah S. Romero-Zaliz, Rocio Hintsanen, Mirka Cloninger, Kevin M. Garcia, Danilo Svrakic, Dragan M. Lester, Nigel Rozsa, Sandor Mesa, Alberto Lyytikainen, Leo-Pekka Giegling, Ina Kahonen, Mika Martinez, Maribel Seppala, Ilkka Raitoharju, Emma de Erausquin, Gabriel A. Mamah, Daniel Raitakari, Olli Rujescu, Dan Postolache, Teodor T. Gu, C. Charles Sung, Joohon Lehtimäki, Terho Keltikangas-Jarvinen, Liisa Cloninger, C. Robert 2022-02-17T16:18:05Z 2022-02-17T16:18:05Z 2021-08
dc.identifier.citation Zwir , I , Del-Val , C , Arnedo , J , Pulkki-Råback , L , Konte , B , Yang , S S , Romero-Zaliz , R , Hintsanen , M , Cloninger , K M , Garcia , D , Svrakic , D M , Lester , N , Rozsa , S , Mesa , A , Lyytikainen , L-P , Giegling , I , Kahonen , M , Martinez , M , Seppala , I , Raitoharju , E , de Erausquin , G A , Mamah , D , Raitakari , O , Rujescu , D , Postolache , T T , Gu , C C , Sung , J , Lehtimäki , T , Keltikangas-Jarvinen , L & Cloninger , C R 2021 , ' Three genetic-environmental networks for human personality ' , Molecular Psychiatry , vol. 26 , no. 8 , pp. 3858-3875 .
dc.identifier.other PURE: 174237754
dc.identifier.other PURE UUID: c4868039-86b9-40b3-9f2b-633cc96a88e7
dc.identifier.other WOS: 000731712800018
dc.identifier.other ORCID: /0000-0002-7977-3852/work/108462758
dc.description.abstract Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems of learning and memory that regulate (1) associative conditioning, (2) intentionality, and (3) self-awareness. We have uncovered largely disjoint sets of genes regulating these dissociable learning processes in different clusters of people with (1) unregulated temperament profiles (i.e., associatively conditioned habits and emotional reactivity), (2) organized character profiles (i.e., intentional self-control of emotional conflicts and goals), and (3) creative character profiles (i.e., self-aware appraisal of values and theories), respectively. However, little is known about how these temperament and character components of personality are jointly organized and develop in an integrated manner. In three large independent genome-wide association studies from Finland, Germany, and Korea, we used a data-driven machine learning method to uncover joint phenotypic networks of temperament and character and also the genetic networks with which they are associated. We found three clusters of similar numbers of people with distinct combinations of temperament and character profiles. Their associated genetic and environmental networks were largely disjoint, and differentially related to distinct forms of learning and memory. Of the 972 genes that mapped to the three phenotypic networks, 72% were unique to a single network. The findings in the Finnish discovery sample were blindly and independently replicated in samples of Germans and Koreans. We conclude that temperament and character are integrated within three disjoint networks that regulate healthy longevity and dissociable systems of learning and memory by nearly disjoint sets of genetic and environmental influences. en
dc.format.extent 18
dc.language.iso eng
dc.relation.ispartof Molecular Psychiatry
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject BASAL GANGLIA
dc.subject HEALTHY TWIN
dc.subject TEMPERAMENT
dc.subject MODEL
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Three genetic-environmental networks for human personality en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Psychosocial factors and health
dc.contributor.organization Medicum
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1359-4184
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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