Patients with rheumatoid arthritis have impaired long-term outcomes after myocardial infarction : a nationwide case-control registry study

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http://hdl.handle.net/10138/340605

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Palomäki , A , Kerola , A M , Malmberg , M , Rautava , P & Kyto , V 2021 , ' Patients with rheumatoid arthritis have impaired long-term outcomes after myocardial infarction : a nationwide case-control registry study ' , Rheumatology , vol. 60 , no. 11 , pp. 5205-5215 . https://doi.org/10.1093/rheumatology/keab204

Title: Patients with rheumatoid arthritis have impaired long-term outcomes after myocardial infarction : a nationwide case-control registry study
Author: Palomäki, Antti; Kerola, Anne M.; Malmberg, Markus; Rautava, Päivi; Kyto, Ville
Contributor organization: Institute for Molecular Medicine Finland
Helsinki Institute of Life Science HiLIFE
HYKS erva
Päijät-Häme Welfare Consortium
Date: 2021-11
Language: eng
Number of pages: 11
Belongs to series: Rheumatology
ISSN: 1462-0324
DOI: https://doi.org/10.1093/rheumatology/keab204
URI: http://hdl.handle.net/10138/340605
Abstract: Objective. To investigate the long-term outcomes of patients with RA after myocardial infarction (MI). Methods. All-comer, real-life MI patients with RA (n = 1614, mean age 74 years) were retrospectively compared with propensity score (1,5) matched MI patients without RA (n = 8070) in a multicentre, nationwide, cohort register study in Finland. The impact of RA duration and the usage of corticosteroids and antirheumatic drugs on RA patients' outcomes were also studied. The median follow-up was 7.3 years. Results. RA was associated with an increased 14-year mortality risk after MI compared with patients without RA [80.4% vs 72.3%; hazard ratio (HR) 1.25; CI, 1.16, 1.35; P Conclusion. RA is independently associated with poorer prognosis after MI. RA duration and corticosteroid usage and dosage were independent predictors of mortality after MI in RA. Special attention is needed for improvement of outcomes after MI in this vulnerable population.
Subject: Cohort study
coronary artery disease
myocardial infarction
outcomes
rheumatoid arthritis
NECROSIS-FACTOR INHIBITORS
CORONARY-HEART-DISEASE
CARDIOVASCULAR MORTALITY
SECONDARY PREVENTION
RISK
EVENTS
CORTICOSTEROIDS
DISCONTINUATION
METAANALYSIS
IMPACT
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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