Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease

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http://hdl.handle.net/10138/340637

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EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group , Jost , S T , Visser-Vandewalle , V , Rizos , A & Pekkonen , E 2021 , ' Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease ' , NPJ Parkinson's disease , vol. 7 , no. 1 , 48 . https://doi.org/10.1038/s41531-021-00174-x

Julkaisun nimi: Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
Tekijä: EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group; Jost, Stefanie T.; Visser-Vandewalle, Veerle; Rizos, Alexandra; Pekkonen, Eero
Tekijän organisaatio: HUS Neurocenter
Neurologian yksikkö
Helsinki University Hospital Area
Päiväys: 2021-12
Kieli: eng
Sivumäärä: 7
Kuuluu julkaisusarjaan: NPJ Parkinson's disease
ISSN: 2373-8057
DOI-tunniste: https://doi.org/10.1038/s41531-021-00174-x
URI: http://hdl.handle.net/10138/340637
Tiivistelmä: To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable “QoL responders”/“non-responders”. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as “QoL non-responders”. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as ‘difficulties experiencing pleasure’ and ‘problems sustaining concentration’. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.
Kuvaus: Publisher Copyright: © 2021, The Author(s).
Avainsanat: 3112 Neurosciences
3124 Neurology and psychiatry
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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