Pelvic sentinel lymph nodes have minimal impact on survival in melanoma patients

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Vuoristo , M , Muhonen , T , Koljonen , V , Juteau , S , Hernberg , M , Ilmonen , S & Jahkola , T 2021 , ' Pelvic sentinel lymph nodes have minimal impact on survival in melanoma patients ' , BJS open , vol. 5 , no. 6 , zrab128 . https://doi.org/10.1093/bjsopen/zrab128

Title: Pelvic sentinel lymph nodes have minimal impact on survival in melanoma patients
Author: Vuoristo, Mikko; Muhonen, Timo; Koljonen, Virve; Juteau, Susanna; Hernberg, Micaela; Ilmonen, Suvi; Jahkola, Tiina
Contributor organization: HUS Musculoskeletal and Plastic Surgery
Plastiikkakirurgian yksikkö
Clinicum
Department of Oncology
University of Helsinki
HUS Comprehensive Cancer Center
Department of Surgery
Department of Pathology
HUSLAB
Date: 2021-11-09
Language: eng
Number of pages: 8
Belongs to series: BJS open
ISSN: 2044-6055
DOI: https://doi.org/10.1093/bjsopen/zrab128
URI: http://hdl.handle.net/10138/340655
Abstract: BACKGROUND: Lower limb or trunk melanoma often presents with femoral and pelvic sentinel lymph nodes (SLNs). The benefits of harvesting pelvic lymph nodes remain controversial. In this retrospective study, the frequency and predictors of pelvic SLNs (PSLNs), and the impact of PSLNs on survival and staging was investigated. METHODS: Altogether 285 patients with cutaneous melanoma located in the lower limb or trunk underwent sentinel lymph node biopsy of the inguinal/iliac lymph node basin at Helsinki University Hospital from 2009-2013. Patient characteristics, detailed pathology reports and follow-up data were retrieved from hospital files. Subgroups of patients categorized by presence of PSLNs were compared for outcome parameters including progression-free survival, melanoma-specific survival and groin recurrence. RESULTS: Superficial femoral/inguinal SLNs were present in all patients and 199 (69.8 per cent) also had PSLNs removed. Median number of SLNs per patient was five and median number of PSLNs was two. Sixty-three patients (22.1 per cent) had metastases in their SLNs and seven (2.5 per cent) had metastases in PSLNs. A single patient had metastases solely in PSLNs, while superficial SLNs remained negative. Harvesting PSLNs or the number of PSLNs retrieved had no impact on progression-free survival or overall survival. The removal of PSLNs did not affect the risk of postoperative seroma or lymphoedema. The only predictor of positive PSLNs was radioactivity count equal to or more than that of the hottest superficial SLNs. CONCLUSION: Pelvic SLNs have minimal clinical impact on the outcome of melanoma patients especially in cases with negative superficial femoral/inguinal SLNs. Removal of PSLNs should be considered when they are the most radioactive nodes or equal to the hottest superficial femoral/inguinal SLNs in lymphoscintigraphy or during surgery.Preliminary results were presented in part at the International Sentinel Node Society Biennial Meeting, Tokyo, Japan, 11-13 October 2018.
Description: Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.
Subject: 3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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