Pelvic sentinel lymph nodes have minimal impact on survival in melanoma patients

Show simple item record Vuoristo, Mikko Muhonen, Timo Koljonen, Virve Juteau, Susanna Hernberg, Micaela Ilmonen, Suvi Jahkola, Tiina 2022-02-18T15:31:01Z 2022-02-18T15:31:01Z 2021-11-09
dc.identifier.citation Vuoristo , M , Muhonen , T , Koljonen , V , Juteau , S , Hernberg , M , Ilmonen , S & Jahkola , T 2021 , ' Pelvic sentinel lymph nodes have minimal impact on survival in melanoma patients ' , BJS open , vol. 5 , no. 6 , zrab128 .
dc.identifier.other PURE: 174281098
dc.identifier.other PURE UUID: 2d090b19-bddb-4bf7-93d6-624723ad57ce
dc.identifier.other Scopus: 85122771341
dc.identifier.other PubMed: 34904646
dc.identifier.other ORCID: /0000-0003-0398-4829/work/108463281
dc.identifier.other WOS: 000753113400022
dc.description Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.
dc.description.abstract BACKGROUND: Lower limb or trunk melanoma often presents with femoral and pelvic sentinel lymph nodes (SLNs). The benefits of harvesting pelvic lymph nodes remain controversial. In this retrospective study, the frequency and predictors of pelvic SLNs (PSLNs), and the impact of PSLNs on survival and staging was investigated. METHODS: Altogether 285 patients with cutaneous melanoma located in the lower limb or trunk underwent sentinel lymph node biopsy of the inguinal/iliac lymph node basin at Helsinki University Hospital from 2009-2013. Patient characteristics, detailed pathology reports and follow-up data were retrieved from hospital files. Subgroups of patients categorized by presence of PSLNs were compared for outcome parameters including progression-free survival, melanoma-specific survival and groin recurrence. RESULTS: Superficial femoral/inguinal SLNs were present in all patients and 199 (69.8 per cent) also had PSLNs removed. Median number of SLNs per patient was five and median number of PSLNs was two. Sixty-three patients (22.1 per cent) had metastases in their SLNs and seven (2.5 per cent) had metastases in PSLNs. A single patient had metastases solely in PSLNs, while superficial SLNs remained negative. Harvesting PSLNs or the number of PSLNs retrieved had no impact on progression-free survival or overall survival. The removal of PSLNs did not affect the risk of postoperative seroma or lymphoedema. The only predictor of positive PSLNs was radioactivity count equal to or more than that of the hottest superficial SLNs. CONCLUSION: Pelvic SLNs have minimal clinical impact on the outcome of melanoma patients especially in cases with negative superficial femoral/inguinal SLNs. Removal of PSLNs should be considered when they are the most radioactive nodes or equal to the hottest superficial femoral/inguinal SLNs in lymphoscintigraphy or during surgery.Preliminary results were presented in part at the International Sentinel Node Society Biennial Meeting, Tokyo, Japan, 11-13 October 2018. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof BJS open
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Pelvic sentinel lymph nodes have minimal impact on survival in melanoma patients en
dc.type Article
dc.contributor.organization HUS Musculoskeletal and Plastic Surgery
dc.contributor.organization Plastiikkakirurgian yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Department of Oncology
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Department of Surgery
dc.contributor.organization Department of Pathology
dc.contributor.organization HUSLAB
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2044-6055
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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