Hypothesis : Chemical activity regulates and coordinates the processes maintaining glycerophospholipid homeostasis in mammalian cells

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Somerharju , P , Virtanen , J A & Hermansson , M 2020 , ' Hypothesis : Chemical activity regulates and coordinates the processes maintaining glycerophospholipid homeostasis in mammalian cells ' , FASEB BioAdvances , vol. 2 , no. 3 , pp. 182-187 . https://doi.org/10.1096/fba.2019-00058

Title: Hypothesis : Chemical activity regulates and coordinates the processes maintaining glycerophospholipid homeostasis in mammalian cells
Author: Somerharju, Pentti; Virtanen, Jorma A.; Hermansson, Martin
Contributor organization: Doctoral Programme Brain & Mind
Biosciences
HUS Head and Neck Center
Department of Public Health
Date: 2020-03
Language: eng
Number of pages: 6
Belongs to series: FASEB BioAdvances
ISSN: 2573-9832
DOI: https://doi.org/10.1096/fba.2019-00058
URI: http://hdl.handle.net/10138/340680
Abstract: Mammalian cells maintain the complex glycerophospholipid (GPL) class compositions of their various membranes within close limits because this is essential to their well-being or viability. Surprisingly, however, it is still not understood how those compositions are maintained except that GPL synthesis and degradation are closely coordinated. Here, we hypothesize that abrupt changes in the chemical activity of the individual GPL classes coordinate synthesis and degradation as well other the homeostatic processes. We have previously proposed that only a limited number of “allowed” or “optimal” GPL class compositions exist in cellular membranes because those compositions are energetically more favorable than others, that is, they represent local free energy minima (Somerharju et al 2009, Biochim. Biophys. Acta 1788, 12-23). This model, however, could not satisfactorily explain how the “optimal” compositions are sensed by the key homeostatic enzymes, that is, rate-limiting synthetizing enzymes and homeostatic phospholipases. We now hypothesize that when the mole fraction of a GPL class exceeds an optimal value, its chemical activity abruptly increases which (a) increases its propensity to efflux from the membrane thus making it susceptible for hydrolysis by homeostatic phospholipases; (b) increases its potency to inhibit its own biosynthesis via a feedback mechanism; (c) enhances its conversion to another glycerophospholipid class via a novel process termed “head group remodeling” or (d) enhances its translocation to other subcellular membranes. In summary, abrupt change in the chemical activity of the individual GPL classes is proposed to regulate and coordinate those four processes maintaining GPL class homeostasis in mammalian cells.
Subject: coordination
homeostasis
maintenance
metabolism
set point
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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