Effectiveness of third-class biologic treatment in crohn’s disease : A multi-center retrospective cohort study

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Albshesh , A , Taylor , J , Savarino , E V , Truyens , M , Armuzzi , A , Ribaldone , D G , Shitrit , A B G , Fibelman , M , Molander , P , Liefferinckx , C , Nancey , S , Korani , M , Rutka , M , Acosta , M B D , Domislovic , V , Suris , G , Eriksson , C , Alves , C , Mpitouli , A , Di Jiang , C , Tepeš , K , Coletta , M , Foteinogiannopoulou , K , Gisbert , J P , Amir-Barak , H , Attauabi , M , Seidelin , J , Afif , W , Marinelli , C , Lobaton , T , Pugliese , D , Maharshak , N , Cremer , A , Limdi , J K , Molnár , T , Otero-Alvarin , B , Krznaric , Z , Magro , F , Karmiris , K , Raine , T , Drobne , D , Koutroubakis , I , Chaparro , M , Yanai , H , Burisch , J & Kopylov , U 2021 , ' Effectiveness of third-class biologic treatment in crohn’s disease : A multi-center retrospective cohort study ' , Journal of clinical medicine , vol. 10 , no. 13 , 2914 . https://doi.org/10.3390/jcm10132914

Title: Effectiveness of third-class biologic treatment in crohn’s disease : A multi-center retrospective cohort study
Author: Albshesh, Ahmad; Taylor, Joshua; Savarino, Edoardo V.; Truyens, Marie; Armuzzi, Alessandro; Ribaldone, Davide G.; Shitrit, Ariella Bar Gil; Fibelman, Morine; Molander, Pauliina; Liefferinckx, Claire; Nancey, Stephane; Korani, Mohamed; Rutka, Mariann; Acosta, Manuel Barreiro De; Domislovic, Viktor; Suris, Gerard; Eriksson, Carl; Alves, Catarina; Mpitouli, Afroditi; Di Jiang, Caroline; Tepeš, Katja; Coletta, Marina; Foteinogiannopoulou, Kalliopi; Gisbert, Javier P.; Amir-Barak, Hadar; Attauabi, Mohamed; Seidelin, Jakob; Afif, Waqqas; Marinelli, Carla; Lobaton, Triana; Pugliese, Daniela; Maharshak, Nitsan; Cremer, Anneline; Limdi, Jimmy K.; Molnár, Tamás; Otero-Alvarin, Borja; Krznaric, Zeljko; Magro, Fernando; Karmiris, Konstantinos; Raine, Tim; Drobne, David; Koutroubakis, Ioannis; Chaparro, Maria; Yanai, Henit; Burisch, Johan; Kopylov, Uri
Contributor organization: HUS Abdominal Center
Gastroenterologian yksikkö
Department of Medicine
Date: 2021-07-01
Language: eng
Number of pages: 13
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
DOI: https://doi.org/10.3390/jcm10132914
URI: http://hdl.handle.net/10138/340708
Abstract: Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn’s disease (CD) failing anti-Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described. Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD. Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second-and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second-and VDZ as a third-class therapy (group B). At week 16–22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5). Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.
Description: Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Subject: Anti-TNF failure
Crohn’s disease
Treatment failure
Treatment response
Ustekinumab
Vedolizumab
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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