Sleep during menopausal transition : A 10-year follow-up

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Kalleinen , N , Aittokallio , J , Lampio , L , Kaisti , M , Polo-Kantola , P , Polo , O , Heinonen , O J & Saaresranta , T 2021 , ' Sleep during menopausal transition : A 10-year follow-up ' , Sleep , vol. 44 , no. 6 , zsaa283 . https://doi.org/10.1093/sleep/zsaa283

Title: Sleep during menopausal transition : A 10-year follow-up
Author: Kalleinen, Nea; Aittokallio, Jenni; Lampio, Laura; Kaisti, Matti; Polo-Kantola, Päivi; Polo, Olli; Heinonen, Olli J.; Saaresranta, Tarja
Contributor organization: HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
Clinicum
Helsinki University Hospital Area
Date: 2021-06-01
Language: eng
Number of pages: 8
Belongs to series: Sleep
ISSN: 0161-8105
DOI: https://doi.org/10.1093/sleep/zsaa283
URI: http://hdl.handle.net/10138/340738
Abstract: Study Objectives: A 10-year observational follow-up study to evaluate the changes in sleep architecture during the menopausal transition. Methods: Fifty-seven premenopausal women (mean age 46 years, SD 0.9) were studied at baseline and after a 10-year follow-up. At both time points, polysomnography (PSG) was performed, and the serum follicle-stimulating hormone (S-FSH) concentration was measured. Linear regression models were used to study the effects of aging and menopause (assessed as change in S-FSH) on sleep. Results: After controlling for body mass index, vasomotor, and depressive symptoms, higher S-FSH level was associated with longer sleep latency (B 0.45, 95% confidence interval [CI]: 0.07 to 0.83). Aging of 10 years was associated with shorter sleep latency (B -46.8, 95% CI: -77.2 to -16.4), shorter latency to stage 2 sleep (B -50.6, 95% CI: -85.3 to -15.9), decreased stage 2 sleep (B -12.4, 95% CI: -21.4 to -3.4), and increased slow-wave sleep (B 12.8, 95% CI: 2.32 to 23.3) after controlling for confounding factors. Conclusions: This study suggests that PSG measured sleep of middle-aged women does not worsen over a 10-year time span due to the menopausal transition. The observed changes seem to be rather age- than menopause-dependent.
Description: Publisher Copyright: © 2020 Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society.
Subject: aging
follicle stimulating hormone (FSH)
menopause
polysomnography (PSG)
sleep architecture
sleep latency
slow-wave sleep (SWS)
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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