Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

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http://hdl.handle.net/10138/340836

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LifeLines Cohort Study , Sun , D , Richard , M A , Musani , S K & Kilpeläinen , T O 2021 , ' Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits ' , HGG advances , vol. 2 , no. 1 , 100013 . https://doi.org/10.1016/j.xhgg.2020.100013

Titel: Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits
Författare: LifeLines Cohort Study; Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Kilpeläinen, Tuomas O.
Upphovmannens organisation: HUS Abdominal Center
Faculty of Medicine
University of Helsinki
Department of Psychology and Logopedics
Psychosocial factors and health
Datum: 2021-01-14
Språk: eng
Sidantal: 12
Tillhör serie: HGG advances
ISSN: 2666-2477
DOI: https://doi.org/10.1016/j.xhgg.2020.100013
Permanenta länken (URI): http://hdl.handle.net/10138/340836
Abstrakt: Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A and PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5 and CHODL). These findings underscore the importance of considering psychological and social factors in gene discovery for BP, especially in non-European populations.
Beskrivning: Publisher Copyright: © 2020 The Author(s)
Subject: blood pressure
depressive symptoms
gene-environment interaction
genome-wide association study
GWAS
GxE
hypertension
psychosocial factors
3111 Biomedicine
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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