Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

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dc.contributor.author LifeLines Cohort Study
dc.contributor.author Sun, Daokun
dc.contributor.author Richard, Melissa A.
dc.contributor.author Musani, Solomon K.
dc.contributor.author Kilpeläinen, Tuomas O.
dc.date.accessioned 2022-02-23T08:04:01Z
dc.date.available 2022-02-23T08:04:01Z
dc.date.issued 2021-01-14
dc.identifier.citation LifeLines Cohort Study , Sun , D , Richard , M A , Musani , S K & Kilpeläinen , T O 2021 , ' Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits ' , HGG advances , vol. 2 , no. 1 , 100013 . https://doi.org/10.1016/j.xhgg.2020.100013
dc.identifier.other PURE: 174458826
dc.identifier.other PURE UUID: 239221a3-7618-4ef0-8e87-52967369ef88
dc.identifier.other Scopus: 85119177602
dc.identifier.uri http://hdl.handle.net/10138/340836
dc.description Publisher Copyright: © 2020 The Author(s)
dc.description.abstract Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A and PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5 and CHODL). These findings underscore the importance of considering psychological and social factors in gene discovery for BP, especially in non-European populations. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof HGG advances
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject blood pressure
dc.subject depressive symptoms
dc.subject gene-environment interaction
dc.subject genome-wide association study
dc.subject GWAS
dc.subject GxE
dc.subject hypertension
dc.subject psychosocial factors
dc.subject 3111 Biomedicine
dc.title Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits en
dc.type Article
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Faculty of Medicine
dc.contributor.organization University of Helsinki
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Psychosocial factors and health
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.xhgg.2020.100013
dc.relation.issn 2666-2477
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.identifier.url http://www.scopus.com/inward/record.url?scp=85119177602&partnerID=8YFLogxK

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