Withdrawal from long-term use of unusually high-dose oxazepam

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Mustonen , A , Leijala , J , Aronranta , J , Lassila , A , Aalto , M & Koskimäki , J 2021 , ' Withdrawal from long-term use of unusually high-dose oxazepam ' , Case Reports in Psychiatry , vol. 2021 , 2140723 . https://doi.org/10.1155/2021/2140723

Title: Withdrawal from long-term use of unusually high-dose oxazepam
Author: Mustonen, Antti; Leijala, Juhani; Aronranta, Johanna; Lassila, Antero; Aalto, Mauri; Koskimäki, Janne
Contributor organization: Clinicum
University of Helsinki
Neuroscience Center
Helsinki Institute of Life Science HiLIFE
Date: 2021
Language: eng
Number of pages: 4
Belongs to series: Case Reports in Psychiatry
ISSN: 2090-682X
DOI: https://doi.org/10.1155/2021/2140723
URI: http://hdl.handle.net/10138/340838
Abstract: Benzodiazepine (BZD) misuse is a worldwide problem that healthcare professionals encounter in daily practice. High-dose BZD withdrawal is usually a long process that may require referral to an inpatient rehabilitation unit. Relapses after withdrawal are common. BZD withdrawal can cause complications including seizures, suicidal behavior, anxiety, and depression. Guidelines describe tapering protocols for modest doses; however, protocols for exceptionally high-dose BZD withdrawal are not well described. Herein, we describe a BZD tapering protocol for a patient with daily use of high-dose (1800 mg) oxazepam (OXP). The BZD tapering was administered in an inpatient psychiatric hospital, and the outcome was evaluated monthly after discharge for three months. This report describes a unique case of high-dose OXP withdrawal and also outlines an optional protocol to apply when clinicians encounter these unusual cases.
Description: Publisher Copyright: Copyright © 2021 Antti Mustonen et al.
Subject: 3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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