Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

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dc.contributor.author Siewert, Katherine M.
dc.contributor.author Klarin, Derek
dc.contributor.author Damrauer, Scott M.
dc.contributor.author Chang, Kyong Mi
dc.contributor.author Tsao, Philip S.
dc.contributor.author Assimes, Themistocles L.
dc.contributor.author Smith, George Davey
dc.contributor.author Voight, Benjamin F.
dc.contributor.author Anttila, Verneri
dc.contributor.author Palta, Priit
dc.contributor.author Muona, Mikko
dc.contributor.author Kallela, Kaarlo Mikko
dc.contributor.author Koiranen, Markku
dc.contributor.author Lehtimäki, Terho
dc.contributor.author Sarin, Antti-Pekka
dc.contributor.author Wedenoja, Juho
dc.contributor.author Färkkilä, Markus
dc.contributor.author Artto, Ville
dc.contributor.author Kaunisto, Mari
dc.contributor.author Vepsäläinen, Salli
dc.contributor.author Kurki, Mitja Ilari
dc.contributor.author Hämäläinen, Eija Inkeri
dc.contributor.author Eriksson, Johan G.
dc.contributor.author Salomaa, Veikko
dc.contributor.author Heikkilä, Kauko
dc.contributor.author Männikkö, Minna
dc.contributor.author Hiekkala, Marjo
dc.contributor.author Kajanne, Risto
dc.contributor.author Kaprio, Jaakko
dc.contributor.author Aromaa, Arpo J.
dc.contributor.author Raitakari, Olli
dc.contributor.author Järvelin, Marjo-Riitta
dc.contributor.author Wessman, Maija
dc.contributor.author Palotie, Aarno
dc.date.accessioned 2022-03-04T11:59:02Z
dc.date.available 2022-03-04T11:59:02Z
dc.date.issued 2021
dc.identifier.citation Siewert , K M , Klarin , D , Damrauer , S M , Chang , K M , Tsao , P S , Assimes , T L , Smith , G D , Voight , B F , Anttila , V , Palta , P , Muona , M , Kallela , K M , Koiranen , M , Lehtimäki , T , Sarin , A-P , Wedenoja , J , Färkkilä , M , Artto , V , Kaunisto , M , Vepsäläinen , S , Kurki , M I , Hämäläinen , E I , Eriksson , J G , Salomaa , V , Heikkilä , K , Männikkö , M , Hiekkala , M , Kajanne , R , Kaprio , J , Aromaa , A J , Raitakari , O , Järvelin , M-R , Wessman , M & Palotie , A 2021 , ' Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache ' , International Journal of Epidemiology , vol. 49 , no. 3 , pp. 1022-1031 . https://doi.org/10.1093/IJE/DYAA050
dc.identifier.other PURE: 175015040
dc.identifier.other PURE UUID: 37ea26a0-0f73-4714-9f97-3319040af80e
dc.identifier.other Scopus: 85089125580
dc.identifier.other PubMed: 32306029
dc.identifier.other ORCID: /0000-0002-2527-5874/work/109259383
dc.identifier.other ORCID: /0000-0002-9256-8028/work/109261981
dc.identifier.other ORCID: /0000-0001-9320-7008/work/109265292
dc.identifier.other ORCID: /0000-0002-6155-0378/work/109265591
dc.identifier.other ORCID: /0000-0002-6946-9195/work/109266116
dc.identifier.other WOS: 000593364900037
dc.identifier.uri http://hdl.handle.net/10138/341303
dc.description.abstract Background: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available. Results: We report multiple phenotypes with genetic correlation (P < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine. Conclusions: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof International Journal of Epidemiology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Genetic correlation
dc.subject Headache
dc.subject Mendelian randomization
dc.subject Migraine
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Genomics of Neurological and Neuropsychiatric Disorders
dc.contributor.organization Medicum
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Clinicum
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Department of Ophthalmology and Otorhinolaryngology
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization HUS Helsinki and Uusimaa Hospital District
dc.contributor.organization Research Programs Unit
dc.contributor.organization Johan Eriksson / Principal Investigator
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization Department of Public Health
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Biosciences
dc.contributor.organization Aarno Palotie / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1093/IJE/DYAA050
dc.relation.issn 0300-5771
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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