Epidemiology of laboratory-confirmed influenza among kidney transplant recipients compared to the general population-A nationwide cohort study

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Helantera , I , Gissler , M , Rimhanen-Finne , R , Ikonen , N , Kanerva , M , Lempinen , M & Finne , P 2021 , ' Epidemiology of laboratory-confirmed influenza among kidney transplant recipients compared to the general population-A nationwide cohort study ' , American Journal of Transplantation , vol. 21 , no. 5 , pp. 1848-1856 . https://doi.org/10.1111/ajt.16421

Title: Epidemiology of laboratory-confirmed influenza among kidney transplant recipients compared to the general population-A nationwide cohort study
Author: Helantera, Ilkka; Gissler, Mika; Rimhanen-Finne, Ruska; Ikonen, Niina; Kanerva, Mari; Lempinen, Marko; Finne, Patrik
Contributor organization: HUS Abdominal Center
IV kirurgian klinikka
Helsinki University Hospital Area
University of Helsinki
HUS Internal Medicine and Rehabilitation
Infektiosairauksien yksikkö
Department of Medicine
Nefrologian yksikkö
Date: 2021-05
Language: eng
Number of pages: 9
Belongs to series: American Journal of Transplantation
ISSN: 1600-6135
DOI: https://doi.org/10.1111/ajt.16421
URI: http://hdl.handle.net/10138/341363
Abstract: Seasonal influenza causes morbidity and mortality after organ transplantation. We quantified the detection of laboratory-confirmed influenza among kidney transplant recipients compared to the general population in a nationwide cohort. All laboratory-confirmed cases of influenza and hospitalizations due to influenza among all kidney transplant recipients in our country between 1995 and 2017 were captured with database linkage from statutory national registries. Data from the general population of Finland, population 5.5 million, were used for comparisons. Annual incidences of influenza and hospitalizations due to influenza, and standardized incidence ratios (SIR) were calculated. Altogether 3904 kidney transplant recipients with a total follow-up of 37 175 patient-years were included. Incidence of laboratory-confirmed influenza was 9.0 per 1000 patient years in 2003-2019, and 18.0 per 1000 patient years during 2015-2019. The risk of laboratory-confirmed influenza was significantly higher among kidney transplant recipients compared to the general population (SIR 5.1, 95% CI 4.5-5.7). SIR for hospitalization due to influenza was 4.4 (95% CI 3.4-4.7). Mortality of the hospitalized patients was 9%, and 5% of the patients with laboratory-confirmed influenza. Detection of laboratory-confirmed influenza is increased fivefold and risk of hospitalization due to influenza more than fourfold among kidney transplant recipients compared to the general population.
Subject: clinical research
practice
epidemiology
infectious disease
kidney disease
infectious
kidney transplantation
nephrology
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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