Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

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Zhang , J , Ji , C , Zhang , H , Shi , H , Mao , F , Qian , H , Xu , W , Wang , D , Pan , J , Fang , X , Santos , H A & Zhang , X 2022 , ' Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy ' , Science Advances , vol. 8 , no. 2 , 8207 .

Title: Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy
Author: Zhang, Jiahui; Ji, Cheng; Zhang, Hongbo; Shi, Hui; Mao, Fei; Qian, Hui; Xu, Wenrong; Wang, Dongqing; Pan, Jianming; Fang, Xinjian; Santos, Helder A.; Zhang, Xu
Contributor organization: Divisions of Faculty of Pharmacy
Division of Pharmaceutical Chemistry and Technology
Helsinki One Health (HOH)
Drug Research Program
Nanomedicines and Biomedical Engineering
Date: 2022-01
Language: eng
Number of pages: 13
Belongs to series: Science Advances
ISSN: 2375-2548
Abstract: Neutrophils are the most abundant innate immune cells in human circulation; however, their derived exosomes have been rarely studied for tumor treatment. Here, we reported that exosomes from neutrophils (N-Ex) induce tumor cell apoptosis by delivering cytotoxic proteins and activating caspase signaling pathway. In addition, we decorated N-Ex with superparamagnetic iron oxide nanoparticles ( SPIONs) to achieve higher tumor-targeting therapeutic effect. We further fabricated exosome-like nanovesicles from neutrophils (NNVs) at high yield. Compared with liposome-loaded doxorubicin (DOX) and natural NNVs, DOX-loaded NNVs show an improved inhibition of tumor cell proliferation. Moreover, DOX-loaded, SPION-decorated NNVs selectively accumulate at the tumor sites under an external magnetic field, effectively restraining tumor growth and extensively prolonging the survival rate in mice. Overall, a simple and effective method to engineer N-Ex and NNVs at clinical applicable scale was developed, which enables the efficient and safe drug delivery for targeted and combined tumor therapy.
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion

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