Retinal Temperature Determination Based on Photopic Porcine Electroretinogram

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http://hdl.handle.net/10138/341392

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Kaikkonen , O , Turunen , T T , Meller , A , Åhlgren , J & Koskelainen , A 2022 , ' Retinal Temperature Determination Based on Photopic Porcine Electroretinogram ' , IEEE Transactions on Biomedical Engineering , vol. 69 , no. 2 , pp. 991-1002 . https://doi.org/10.1109/TBME.2021.3111533

Title: Retinal Temperature Determination Based on Photopic Porcine Electroretinogram
Author: Kaikkonen, Ossi; Turunen, Teemu T.; Meller, Anna; Åhlgren, Johanna; Koskelainen, Ari
Contributor organization: Helsinki One Health (HOH)
Helsinki Institute of Life Science HiLIFE, Infra
Date: 2022-02
Language: eng
Number of pages: 12
Belongs to series: IEEE Transactions on Biomedical Engineering
ISSN: 0018-9294
DOI: https://doi.org/10.1109/TBME.2021.3111533
URI: http://hdl.handle.net/10138/341392
Abstract: Objective: Subthreshold retinal laser therapy (SLT) is a treatment modality where the temperature of the retinal pigment epithelium (RPE) is briefly elevated to trigger the therapeutic benefits of sublethal heat shock. However, the temperature elevation induced by a laser exposure varies between patients due to individual differences in RPE pigmentation and choroidal perfusion. This study describes an electroretinography (ERG)-based method for controlling the temperature elevation during SLT. Methods: The temperature dependence of the photopic ERG response kinetics were investigated both ex vivo with isolated pig retinas and in vivo with anesthetized pigs by altering the temperature of the subject and recording ERG in different temperatures. A model was created for ERG-based temperature estimation and the feasibility of the model for controlling SLT was assessed through computational simulations. Results: The kinetics of the photopic in vivo flash ERG signaling accelerated between 3.6 and 4.7%/degrees C, depending on the strength of the stimulus. The temperature dependence was 5.0%/degrees C in the entire investigated range of 33 to 44 degrees C in ex vivo ERG. The simulations showed that the method is suitable for determining the steady-state temperature elevation in SLT treatments with a sufficiently long laser exposure and large spot size, e.g., during > 30 s laser exposures with > 3 mm stimulus spot diameter. Conclusions: The described ERG-based temperature estimation model could be used to control SLT treatments such as transpupillary thermotherapy. Significance: The introduced ERG-based method for controlling SLT could improve the repeatability, safety, and efficacy of the treatment of various retinal disorders.
Subject: Retina
Animals
Electrodes
Temperature dependence
Temperature sensors
Medical treatment
Kinetic theory
Electrophysiology
electroretinography
porcine retina
retinal laser therapy
temperature
SUBTHRESHOLD TRANSPUPILLARY THERMOTHERAPY
DIABETIC MACULAR EDEMA
CONVENTIONAL LASER PHOTOCOAGULATION
DIODE MICROPULSE LASER
PHOTODYNAMIC THERAPY
DEGENERATION
MODULATION
EXPRESSION
EYES
217 Medical engineering
413 Veterinary science
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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