Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function

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Laurila , S , Rebelos , E , Lahesmaa , M , Sun , L , Schnabl , K , Peltomaa , T-M , Klen , R , U-Din , M , Honka , M-J , Eskola , O , Kirjavainen , A K , Nummenmaa , L , Klingenspor , M , Virtanen , K A & Nuutila , P 2022 , ' Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function ' , American Journal of Physiology: Endocrinology and Metabolism , vol. 322 , no. 1 , pp. E54-E62 . https://doi.org/10.1152/ajpendo.00260.2021

Title: Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function
Author: Laurila, Sanna; Rebelos, Eleni; Lahesmaa, Minna; Sun, Lihua; Schnabl, Katharina; Peltomaa, Tia-Mari; Klen, Riku; U-Din, Mueez; Honka, Miikka-Juhani; Eskola, Olli; Kirjavainen, Anna K.; Nummenmaa, Lauri; Klingenspor, Martin; Virtanen, Kirsi A.; Nuutila, Pirjo
Contributor organization: Clinicum
Department of Medicine
Helsinki University Hospital Area
Date: 2022-01
Language: eng
Number of pages: 9
Belongs to series: American Journal of Physiology: Endocrinology and Metabolism
ISSN: 0193-1849
DOI: https://doi.org/10.1152/ajpendo.00260.2021
URI: http://hdl.handle.net/10138/342008
Abstract: The cardiac benefits of gastrointestinal hormones have been of interest in recent years. The aim of this study was to explore the myocardial and renal effects of the gastrointestinal hormone secretin in the GUTBAT trial (NCT03290846). A placebo-controlled crossover study was conducted on 15 healthy males in fasting conditions, where subjects were blinded to the intervention. Myocardial glucose uptake was measured with [F-18]2-fluoro-2-deoxy-o-glucose ([F-18]FDG) positron emission tomography. Kidney function was measured with [F-18]FDG renal clearance and estimated glomerular filtration rate (eGFR). Secretin increased myocardial glucose uptake compared with placebo (secretin vs. placebo, means +/- SD, 15.5 +/- 7.4 vs. 9.7 +/- 4.9 gmol/100 g/min, 95% confidence interval (CI) [2.2, 9.4], P = 0.004). Secretin also increased [F-18]FDG renal clearance (44.5 +/- 5.4 vs. 39.5 8.5 mL/min, 95%CI [1.9, 8.1], P = 0.004), and eGFR was significantly increased from baseline after secretin, compared with placebo (17.8 +/- 9.8 vs. 6.0 +/- 5.2 Delta mL/min/1.73 m(2),( ) 95%CI [6.0, 17.6], P = 0.001). Our results implicate that secretin increases heart work and renal filtration, making it an interesting drug candidate for future studies in heart and kidney failure. NEW & NOTEWORTHY Secretin increases myocardial glucose uptake compared with placebo, supporting a previously proposed inotropic effect. Secretin also increased renal filtration rate.
Subject: gastrointestinal hormone
kidney function
myocardial metabolism
secretin
BROWN ADIPOSE-TISSUE
DIURETIC ACTION
GLUCOSE
HEART
THERMOGENESIS
ACTIVATION
PERFUSION
INTERVAL
FAILURE
INSULIN
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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