Ga-68-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism

Show simple item record Boss, Marti Rottenburger, Christof Brenner, Winfried Blankenstein, Oliver Prasad, Vikas Prasad, Sonal de Coppi, Paolo Kuhnen, Peter Buitinga, Mijke Nuutila, Pirjo Otonkoski, Timo Hussain, Khalid Brom, Maarten Eek, Annemarie Bomanji, Jamshed Shah, Pratik Gotthardt, Martin 2022-03-25T08:17:01Z 2022-03-25T08:17:01Z 2022-02-01
dc.identifier.citation Boss , M , Rottenburger , C , Brenner , W , Blankenstein , O , Prasad , V , Prasad , S , de Coppi , P , Kuhnen , P , Buitinga , M , Nuutila , P , Otonkoski , T , Hussain , K , Brom , M , Eek , A , Bomanji , J , Shah , P & Gotthardt , M 2022 , ' Ga-68-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism ' , The Journal of Nuclear Medicine , vol. 63 , no. 2 , pp. 310-315 .
dc.identifier.other PURE: 175720155
dc.identifier.other PURE UUID: 3695c5b5-15aa-4d91-b429-1a40639e9ecc
dc.identifier.other WOS: 000749772400024
dc.description.abstract Surgery with curative intent can be offered to congenital hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled exendin-4 specifically binds the glucagonlike peptide 1 receptor on pancreatic beta-cells. In this study, we compared the performance of F-18-DOPA PET/CT, the current standard imaging method for CHI, and PET/CT with the new tracer Ga-68-NODAGA-exendin-4 in the preoperative detection of focal CHI. Methods: Nineteen CHI patients underwent both F-18-DOPA PET/CT and Ga-68-NODAGA-exendin-4 PET/CT before surgery. The images were evaluated in 3 settings: a standard clinical reading, a masked expert reading, and a joint reading. The target (lesion)-to-nontarget (normal pancreas) ratio was determined using SUVmax. Image quality was rated by pediatric surgeons in a questionnaire. Results: Fourteen of 19 patients having focal lesions underwent surgery. On the basis of clinical readings, the sensitivity of Ga-68-NODAGA-exendin-4 PET/CT (100%; 95% CI, 77%-100%) was higher than that of F-18-DOPA PET/CT (71%; 95% CI, 42%-92%). Interobserver agreement between readings was higher for Ga-68-NODAGA-exendin-4 than for F-18-DOPA PET/CT (Fleiss kappa = 0.91 vs. 0.56). Ga-68-NODAGA-exendin-4 PET/CT provided significantly (P = 0.021) higher target-to-nontarget ratios (2.02 +/- 0.65) than did F-18-DOPA PET/CT (1.40 +/- 0.40). On a 5-point scale, pediatric surgeons rated Ga-68-NODAGA-exendin-4 PET/CT as superior to F-18-DOPA PET/CT. Conclusion: For the detection of focal CHI, Ga-68-NODAGA-exendin-4 PET/CT has higher clinical sensitivity and better interobserver correlation than F-18-DOPA PET/CT. Better contrast and image quality make Ga-68-NODAGA-exendin-4 PET/CT superior to F-18-DOPA PET/CT in surgeons' intraoperative quest for lesion localization. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof The Journal of Nuclear Medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject congenital hyperinsulinism
dc.subject focal CHI
dc.subject diagnostic imaging
dc.subject Ga-68-NODAGA-exendin-4 PET/CT
dc.subject F-18-DOPA PET/CT
dc.subject 11P15 IMPRINTED GENES
dc.subject DIAGNOSIS
dc.subject MANAGEMENT
dc.subject MUTATION
dc.subject CHILDREN
dc.subject INFANCY
dc.subject DIFFUSE
dc.subject FORMS
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Ga-68-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism en
dc.type Article
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization STEMM - Stem Cells and Metabolism Research Program
dc.contributor.organization Centre of Excellence in Stem Cell Metabolism
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Clinicum
dc.contributor.organization Research Programs Unit
dc.contributor.organization Timo Pyry Juhani Otonkoski / Principal Investigator
dc.contributor.organization Children's Hospital
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0161-5505
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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