PUFA omega-3 and omega-6 biomarkers and sleep : a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE)

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Murphy , R A , Tintle , N , Harris , W S , Darvishian , M , Marklund , M , Virtanen , J K , Hantunen , S , de Mello , V D , Tuomilehto , J , Lindstrom , J , Bolt , M A , Brouwer , I A , Wood , A C , Senn , M , Redline , S , Tsai , M Y , Gudnason , V , Eiriksdottir , G , Lindberg , E , Shadyab , A H , Liu , B , Carnethon , M , Uusitupa , M , Djousse , L , Riserus , U , Lind , L , van Dam , R M , Koh , W-P , Shi , P , Siscovick , D , Lemaitre , R N & Mozaffarian , D 2022 , ' PUFA omega-3 and omega-6 biomarkers and sleep : a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE) ' , American Journal of Clinical Nutrition , vol. 115 , no. 3 , pp. 864-876 . https://doi.org/10.1093/ajcn/nqab408

Title: PUFA omega-3 and omega-6 biomarkers and sleep : a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE)
Author: Murphy, Rachel A.; Tintle, Nathan; Harris, William S.; Darvishian, Maryam; Marklund, Matti; Virtanen, Jyrki K.; Hantunen, Sari; de Mello, Vanessa D.; Tuomilehto, Jaakko; Lindstrom, Jaana; Bolt, Matthew A.; Brouwer, Ingeborg A.; Wood, Alexis C.; Senn, Mackenzie; Redline, Susan; Tsai, Michael Y.; Gudnason, Vilmundur; Eiriksdottir, Gudny; Lindberg, Eva; Shadyab, Aladdin H.; Liu, Buyun; Carnethon, Mercedes; Uusitupa, Matti; Djousse, Luc; Riserus, Ulf; Lind, Lars; van Dam, Rob M.; Koh, Woon-Puay; Shi, Peilin; Siscovick, David; Lemaitre, Rozenn N.; Mozaffarian, Dariush
Contributor organization: Clinicum
Department of Public Health
Date: 2022-03-04
Language: eng
Number of pages: 13
Belongs to series: American Journal of Clinical Nutrition
ISSN: 0002-9165
DOI: https://doi.org/10.1093/ajcn/nqab408
URI: http://hdl.handle.net/10138/342563
Abstract: Background: n-3 and n-6 PUFAs have physiologic roles in sleep processes. but little is known regarding circulating n-3 and n-6 PUFA and sleep parameters. Objectives: We sought to assess associations between biomarkers of n-3 and n-6 PUFA intake with self-reported sleep duration and difficulty falling sleeping in the Fatty Acids and Outcome Research Consortium. Methods: Harmonized, de novo. individual-level analyses were performed and pooled across 12 cohorts. Participants were 35-96 y old and from 5 nations. Circulating measures included alpha-linolenic acid (ALA), EPA, docosapentaenoic acid (DPA), DHA, EPA + DPA DHA, linoleic acid, and arachidonic acid. Sleep duration (10 cohorts. n = 18.791) was categorized as short (= 9 h). Difficulty falling asleep (8 cohorts, n = 12,500) was categorized as yes or no. Associations between PUFAs, sleep duration, and difficulty falling sleeping were assessed by cross-sectional multinomial logistic regression using standardized protocols and covariates. Cohort-specific multivariable-adjusted ORs per quintile of PUFAs were pooled with inverse-variance weighted meta-analysis. Results: In pooled analysis adjusted for sociodemographic characteristics and health status, participants with higher very long-chain n-3 PUFAs were less likely to have long sleep duration. In the top compared with the bottom quintiles. the multivariable-adjusted ORs (95% CIs) for long sleep were 0.78 (95% CI: 0.65, 0.95) for DHA and 0.76 (95% CI: 0.63, 0.93) for EPA + DPA + DHA. Significant associations for ALA and n-6 PUFA with short sleep duration or difficulty falling sleeping were not identified. Conclusions: Participants with higher concentrations of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the temporal nature of this relation. These novel findings across 12 cohorts highlight the need for experimental and biological assessments of very long-chain n-3 PUFAs and sleep duration.
Subject: sleep quality
omega-3
fatty acids
diet
public health
biomarkers
CORONARY-HEART-DISEASE
DOCOSAHEXAENOIC ACID
MORTALITY
DURATION
MELATONIN
QUALITY
ASSOCIATIONS
ADULT
LEVEL
RISK
3142 Public health care science, environmental and occupational health
3143 Nutrition
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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