Synchronous spiking associated with prefrontal high y oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus

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Totah , N K , Logothetis , N K & Eschenko , O 2021 , ' Synchronous spiking associated with prefrontal high y oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus ' , Journal of Neurophysiology , vol. 125 , no. 4 , pp. 1191-1201 . https://doi.org/10.1152/jn.00677.2020

Title: Synchronous spiking associated with prefrontal high y oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus
Author: Totah, Nelson K.; Logothetis, Nikos K.; Eschenko, Oxana
Contributor organization: Neural networks for learning and cognitive control
Helsinki Institute of Life Science HiLIFE
Faculty of Pharmacy
Date: 2021-04
Language: eng
Number of pages: 11
Belongs to series: Journal of Neurophysiology
ISSN: 0022-3077
DOI: https://doi.org/10.1152/jn.00677.2020
URI: http://hdl.handle.net/10138/342624
Abstract: The brainstem noradrenergic locus coeruleus (LC) is reciprocally connected with the prefrontal cortex (PFC). Coupling between LC spiking and the depolarizing phase of slow (1?2 Hz) waves in PFC field potentials during sleep and anesthesia suggests that LC drives cortical state transition. Reciprocal LC-PFC connectivity should also allow interactions in the opposing (top-down) direction, but prior work has only studied prefrontal control over LC activity using electrical or optogenetic stimulation. Here, we describe the physiological characteristics of spontaneously occurring top-down LC-PFC interactions. We recorded LC multiunit activity (MUA) simultaneously with PFC single-unit and local field potential (LFP) activity in urethane-anesthetized rats. We observed cross-regional coupling between the phase of 5-Hz oscillations in LC-MUA and the power of PFC LFP 60?200 Hz high y (hy). Transient increases in PFC hy power preceded peaks in the 5-Hz LC-MUA oscillation. Analysis of cross-regional transfer entropy demonstrated that the PFC hy transients were predictive of a transient increase in LC-MUA. An -29 ms delay between these signals was consistent with the conduction velocity from the PFC to the LC. Finally, we showed that PFC hy transients are associated with synchronized spiking of a subset (27%) of PFC single units. Our data suggest that PFC hy transients may indicate the timing of the top-down excitatory input to LC, at least under conditions when LC neuronal population activity fluctuates rhythmically at 5 Hz. Synchronized PFC neuronal spiking that occurs during hy transients may provide a previously unknown mode of top-down control over the LC. NEW & NOTEWORTHY The prefrontal cortex (PFC) is thought to control activity in the noradrenergic locus coeruleus (LC). Prior anatomical and prefrontal stimulation studies demonstrated the potential for PFC-LC interactions; however, it is unknown what types of PFC activity affect the LC. Here, we show that transient increases in PFC high y power and associated changes in PFC unit-pair synchrony are a potential sign of top-down control over the LC.
Subject: y
locus coeruleus
synchrony
0
top-down control
NORADRENERGIC NEURONS
GAMMA OSCILLATIONS
CORTEX
RAT
PROJECTIONS
DYNAMICS
ORGANIZATION
INNERVATION
SYSTEM
HZ
3112 Neurosciences
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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