Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma

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Kaasinen , M , Hagström , J , Mustonen , H , Sorsa , T , Sund , M , Haglund , C & Seppänen , H 2022 , ' Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma ' , International Journal of Molecular Sciences , vol. 23 , no. 6 , 3314 . https://doi.org/10.3390/ijms23063314

Title: Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma
Author: Kaasinen, Mirjami; Hagström, Jaana; Mustonen, Harri; Sorsa, Timo; Sund, Malin; Haglund, Caj; Seppänen, Hanna
Contributor organization: Department of Surgery
Helsinki University Hospital Area
HUSLAB
HUS Head and Neck Center
Medicum
University of Helsinki
Department of Pathology
CAN-PRO - Translational Cancer Medicine Program
HUS Abdominal Center
Clinicum
Department of Oral and Maxillofacial Diseases
II kirurgian klinikka
Date: 2022-03
Language: eng
Number of pages: 13
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms23063314
URI: http://hdl.handle.net/10138/342917
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a significant cause of cancer-related death globally, and, despite improvements in diagnostics and treatment, survival remains poor. Matrix metalloproteinases (MMPs) are enzymes involved in stroma remodelling in inflammation and cancer. MMP-8 plays a varied prognostic role in cancers of the gastrointestinal tract. We examined the prognostic value of MMP-8 immunoexpression in tumour tissue and the amount of MMP-8-positive polymorphonuclear cells (PMNs) in PDAC and their association with immune responses using C-reactive protein (CRP) as a marker of systemic inflammation. Tumour samples from 141 PDAC patients undergoing surgery in 2002-2011 at the Department of Surgery, Helsinki University Hospital were stained immunohistochemically, for which we evaluated MMP-8 expression in cancer cells and the amount of MMP-8-positive PMNs. We assessed survival using the Kaplan-Meier analysis while uni- and multivariable analyses relied on the Cox proportional hazards model. A negative MMP-8 stain and elevated CRP level predicted a poor prognosis (hazard ratio [HR] = 6.95; 95% confidence interval (CI) 2.69-17.93; p < 0.001) compared to a positive stain and low CRP level (
Subject: pancreatic cancer
matrix metalloproteinase 8
polymorphonuclear cell
C-reactive protein
COLLAGENASE-2 MMP-8
LYMPHOCYTE RATIO
CANCER
NEUTROPHILS
SURVIVAL
PROGRESSION
METASTASIS
DIAGNOSIS
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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