Obesity Does Not Protect From Subarachnoid Hemorrhage : Pooled Analyses of 3 Large Prospective Nordic Cohorts

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Rautalin , I , Kaprio , J , Ingebrigtsen , T , Jousilahti , P , Lochen , M-L , Romundstad , P R , Salomaa , V , Vik , A , Wilsgaard , T , Mathiesen , E B , Sandvei , M & Korja , M 2022 , ' Obesity Does Not Protect From Subarachnoid Hemorrhage : Pooled Analyses of 3 Large Prospective Nordic Cohorts ' , Stroke , vol. 53 , no. 4 , pp. 1301-1309 . https://doi.org/10.1161/STROKEAHA.121.034782

Title: Obesity Does Not Protect From Subarachnoid Hemorrhage : Pooled Analyses of 3 Large Prospective Nordic Cohorts
Author: Rautalin, Ilari; Kaprio, Jaakko; Ingebrigtsen, Tor; Jousilahti, Pekka; Lochen, Maja-Lisa; Romundstad, Pal Richard; Salomaa, Veikko; Vik, Anne; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Sandvei, Marie; Korja, Miikka
Contributor organization: Neurokirurgian yksikkö
HUS Neurocenter
Department of Public Health
Institute for Molecular Medicine Finland
University of Helsinki
Date: 2022-04
Language: eng
Number of pages: 9
Belongs to series: Stroke
ISSN: 0039-2499
DOI: https://doi.org/10.1161/STROKEAHA.121.034782
URI: http://hdl.handle.net/10138/342927
Abstract: Background: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether the previously reported inverse association can be explained by modifying effects of the most important risk factors of SAH-smoking and hypertension. Methods: We conducted a collaborative study of three prospective population-based Nordic cohorts by combining comprehensive baseline data from 211 972 adult participants collected between 1972 and 2012, with follow-up until the end of 2018. Primarily, we compared the risk of SAH between three BMI categories: (1) low (BMI= 30) BMI and evaluated the modifying effects of smoking and hypertension on the associations. Results: We identified 831 SAH events (mean age 62 years, 55% women) during the total follow-up of 4.7 million person-years. Compared with the moderate BMI category, persons with low BMI had an elevated risk for SAH (adjusted hazard ratio [HR], 1.30 [1.09-1.55]), whereas no significant risk difference was found in high BMI category (HR, 0.91 [0.73-1.13]). However, we only found the increased risk of low BMI in smokers (HR, 1.49 [1.19-1.88]) and in hypertensive men (HR, 1.72 [1.18-2.50]), but not in nonsmokers (HR, 1.02 [0.76-1.37]) or in men with normal blood pressure values (HR, 0.98 [0.63-1.54]; interaction HRs, 1.68 [1.18-2.41], P=0.004 between low BMI and smoking and 1.76 [0.98-3.13], P=0.06 between low BMI and hypertension in men). Conclusions: Smoking and hypertension appear to explain, at least partly, the previously reported inverse association between BMI and the risk of SAH. Therefore, the independent role of BMI in the risk of SAH is likely modest.
Subject: blood pressure
body mass index
subarachnoid hemorrhage
3112 Neurosciences
3124 Neurology and psychiatry
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion

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