Antitumoral Effect of Plocabulin in High Grade Serous Ovarian Carcinoma Cell Line Models

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Heredia-Soto , V , Escudero , J , Miguel , M , Ruiz , P , Gallego , A , Berjón , A , Hernández , A , Martínez-Díez , M , Zheng , S , Tang , J , Hardisson , D , Feliu , J , Redondo , A & Mendiola , M 2022 , ' Antitumoral Effect of Plocabulin in High Grade Serous Ovarian Carcinoma Cell Line Models ' , Frontiers in oncology , vol. 12 , 862321 . https://doi.org/10.3389/fonc.2022.862321

Title: Antitumoral Effect of Plocabulin in High Grade Serous Ovarian Carcinoma Cell Line Models
Author: Heredia-Soto, Victoria; Escudero, Javier; Miguel, María; Ruiz, Patricia; Gallego, Alejandro; Berjón, Alberto; Hernández, Alicia; Martínez-Díez, Marta; Zheng, Shuyu; Tang, Jing; Hardisson, David; Feliu, Jaime; Redondo, Andrés; Mendiola, Marta
Contributor organization: Research Program in Systems Oncology
Department of Mathematics and Statistics
Medicum
Department of Biochemistry and Developmental Biology
Date: 2022-03-17
Language: eng
Number of pages: 10
Belongs to series: Frontiers in oncology
ISSN: 2234-943X
DOI: https://doi.org/10.3389/fonc.2022.862321
URI: http://hdl.handle.net/10138/343203
Abstract: Ovarian cancer (OC) is a life-threatening tumor and the deadliest among gynecological cancers in developed countries. First line treatment with a carboplatin/paclitaxel regime is initially effective in the majority of patients, but most advanced OC will recur and develop drug resistance. Therefore, the identification of alternative therapies is needed. In this study, we employed a panel of high-grade serous ovarian cancer (HGSOC) cell lines, in monolayer and three-dimensional cell cultures. We evaluated the effects of a novel tubulin-binding agent, plocabulin, on proliferation, cell cycle, migration and invasion. We have also tested combinations of plocabulin with several drugs currently used in OC in clinical practice. Our results show a potent antitumor activity of plocabulin, inhibiting proliferation, disrupting microtubule network, and decreasing their migration and invasion capabilities. We did not observe any synergistic combination of plocabulin with cisplatin, doxorubicin, gemcitabine or trabectedin. In conclusion, plocabulin has a potent antitumoral effect in HGSOC cell lines that warrants further clinical investigation.
Subject: 3D cell culture
CANCER
DOUBLE-BLIND
MAINTENANCE THERAPY
SYNERGY
drug testing
high-grade serous ovarian cancer (HGSOC)
microtubule inhibitor
plocabulin (PM060184)
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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