Reproducibility of extracellular vesicle research

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dc.contributor.author Nieuwland, Rienk
dc.contributor.author Siljander, Pia R.M.
dc.contributor.author Falcón-Pérez, Juan M.
dc.contributor.author Witwer, Kenneth W.
dc.date.accessioned 2022-05-13T06:26:02Z
dc.date.available 2022-05-13T06:26:02Z
dc.date.issued 2022-08
dc.identifier.citation Nieuwland , R , Siljander , P R M , Falcón-Pérez , J M & Witwer , K W 2022 , ' Reproducibility of extracellular vesicle research ' , European Journal of Cell Biology , vol. 101 , no. 3 , 151226 . https://doi.org/10.1016/j.ejcb.2022.151226
dc.identifier.other PURE: 210026337
dc.identifier.other PURE UUID: 746489ef-0b95-4b32-9479-85f7d683f279
dc.identifier.other Scopus: 85128480400
dc.identifier.other ORCID: /0000-0003-2326-5821/work/113020151
dc.identifier.other WOS: 000797651200004
dc.identifier.uri http://hdl.handle.net/10138/343676
dc.description Publisher Copyright: © 2022
dc.description.abstract Cells release membrane-delimited particles into the environment. These particles are called “extracellular vesicles” (EVs), and EVs are present in fluids contacting cells, including body fluids and conditioned culture media. Because EVs change and contribute to health and disease, EVs have become a hot topic. From the thousands of papers now published on EVs annually, one easily gets the impression that EVs provide biomarkers for all diseases, and that EVs are carriers of all relevant biomolecules and are omnipotent therapeutics. At the same time, EVs are heterogeneous, elusive and difficult to study due to their physical properties and the complex composition of their environment. This overview addresses the current challenges encountered when working with EVs, and how we envision that most of these challenges will be overcome in the near future. Right now, an infrastructure is being developed to improve the reproducibility of EV measurement results. This infrastructure comprises expert task forces of the International Society of Extracellular Vesicles (ISEV) developing guidelines and recommendations, instrument calibration, standardized and transparent reporting, and education. Altogether, these developments will support the credibility of EV research by introducing robust reproducibility, which is a prerequisite for understanding their biological significance and biomarker potential. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof European Journal of Cell Biology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject PLASMA
dc.subject SIZE
dc.title Reproducibility of extracellular vesicle research en
dc.type Article
dc.contributor.organization Extracellular Vesicles
dc.contributor.organization Molecular and Integrative Biosciences Research Programme
dc.contributor.organization University of Helsinki
dc.contributor.organization Faculty of Biological and Environmental Sciences
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ejcb.2022.151226
dc.relation.issn 0171-9335
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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