State-dependent TMS effects in the visual cortex after visual adaptation : A combined TMS-EEG study

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http://hdl.handle.net/10138/344249

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Guzman-Lopez , J , Hernandez-Pavon , J C , Lioumis , P , Mäkelä , J P & Silvanto , J 2022 , ' State-dependent TMS effects in the visual cortex after visual adaptation : A combined TMS-EEG study ' , Clinical Neurophysiology , vol. 134 , pp. 129-136 . https://doi.org/10.1016/j.clinph.2021.08.020

Title: State-dependent TMS effects in the visual cortex after visual adaptation : A combined TMS-EEG study
Author: Guzman-Lopez, Jessica; Hernandez-Pavon, Julio C.; Lioumis, Pantelis; Mäkelä, Jyrki P.; Silvanto, Juha
Contributor organization: BioMag Laboratory
HUS Medical Imaging Center
Faculty Common Matters
University of Helsinki
Date: 2022-02
Language: eng
Number of pages: 8
Belongs to series: Clinical Neurophysiology
ISSN: 1388-2457
DOI: https://doi.org/10.1016/j.clinph.2021.08.020
URI: http://hdl.handle.net/10138/344249
Abstract: Objective: The impact of transcranial magnetic stimulation (TMS) has been shown to depend on the initial brain state of the stimulated cortical region. This observation has led to the development of paradigms that aim to enhance the specificity of TMS effects by using visual/luminance adaptation to modulate brain state prior to the application of TMS. However, the neural basis of interactions between TMS and adaptation is unknown. Here, we examined these interactions by using electroencephalography (EEG) to measure the impact of TMS over the visual cortex after luminance adaptation. Methods: Single-pulses of neuronavigated TMS (nTMS) were applied at two different intensities over the left visual cortex after adaptation to either high or low luminance. We then analyzed the effects of adaptation on the global and local cortical excitability. Results: The analysis revealed a significant interaction between the TMS-evoked responses and the adaptation condition. In particular, when nTMS was applied with high intensity, the evoked responses were larger after adaptation to high than low luminance.Conclusion: This result provides the first neural evidence on the interaction between TMS with visual adaptation. Significance: TMS can activate neurons differentially as a function of their adaptation state.(c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject: Transcranial magnetic stimulation
Electroencephalography
Visual cortex
Adaptation
Luminance
TRANSCRANIAL MAGNETIC STIMULATION
NEURONAL RESPONSES
LIGHT ADAPTATION
BRAIN
EXCITABILITY
COMPONENTS
DIRECTION
GANGLION
REVEALS
3112 Neurosciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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