Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Show full item record



Permalink

http://hdl.handle.net/10138/345525

Citation

Lampinen , R , Belaya , I , Saveleva , L , Liddell , J R , Rait , D , Huuskonen , M T , Giniatullina , R , Sorvari , A , Soppela , L , Mikhailov , N , Boccuni , I , Giniatullin , R , Cruz-Haces , M , Konovalova , J , Koskuvi , M , Domanskyi , A , Hämäläinen , R H , Goldsteins , G , Koistinaho , J , Malm , T , Chew , S , Rilla , K , White , A R , Marsh-Armstrong , N & Kanninen , K M 2022 , ' Neuron-astrocyte transmitophagy is altered in Alzheimer's disease ' , Neurobiology of Disease , vol. 170 , 105753 . https://doi.org/10.1016/j.nbd.2022.105753

Title: Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
Author: Lampinen, Riikka; Belaya, Irina; Saveleva, Liudmila; Liddell, Jeffrey R.; Rait, Dzhessi; Huuskonen, Mikko T.; Giniatullina, Raisa; Sorvari, Annika; Soppela, Liisi; Mikhailov, Nikita; Boccuni, Isabella; Giniatullin, Rashid; Cruz-Haces, Marcela; Konovalova, Julia; Koskuvi, Marja; Domanskyi, Andrii; Hämäläinen, Riikka H.; Goldsteins, Gundars; Koistinaho, Jari; Malm, Tarja; Chew, Sweelin; Rilla, Kirsi; White, Anthony R.; Marsh-Armstrong, Nicholas; Kanninen, Katja M.
Contributor organization: Institute of Biotechnology
Biosciences
Neuroscience Center
Date: 2022-08
Language: eng
Number of pages: 13
Belongs to series: Neurobiology of Disease
ISSN: 0969-9961
DOI: https://doi.org/10.1016/j.nbd.2022.105753
URI: http://hdl.handle.net/10138/345525
Abstract: Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmitophagy is altered in Alzheimer's disease (AD). Here we report that the internalization of neuronal mitochondria is significantly increased in astrocytes isolated from AD mouse brains. We also demonstrate that the degradation of neuronal mitochondria by astrocytes is increased in AD mice at the age of 6 months onwards. Furthermore, we demonstrate for the first time a similar phenomenon between human neurons and AD astrocytes, and in murine hippocampi in vivo. The results suggest the involvement of S100a4 in impaired mitochondrial transfer between neurons and AD astrocytes together with significant increases in the mitophagy regulator and reactive oxygen species in aged AD astrocytes. These findings demonstrate altered neuronsupporting functions of AD astrocytes and provide a starting point for studying the molecular mechanisms of transmitophagy in AD.
Subject: Alzheimer's disease
Astrocytes
Mitochondria
Mitophagy
Transmitophagy
MITOCHONDRIAL DYSFUNCTION
ACCUMULATION
EXPRESSION
MITOPHAGY
AUTOPHAGY
S100A4
PARKIN
MODEL
MICE
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0969996122001450_main.pdf 3.385Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record