The socioeconomic landscape of the exposome during pregnancy

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Sum , K K , Tint , M T , Aguilera , R , Dickens , B S L , Choo , S , Ang , L T , Phua , D , Law , E C , Ng , S , Tan , K M-L , Benmarhnia , T , Karnani , N , Eriksson , J G , Chong , Y-S , Yap , F , Tan , K H , Lee , Y S , Chan , S-Y , Chong , M F F & Huang , J 2022 , ' The socioeconomic landscape of the exposome during pregnancy ' , Environment International , vol. 163 , 107205 . https://doi.org/10.1016/j.envint.2022.107205

Title: The socioeconomic landscape of the exposome during pregnancy
Author: Sum, Ka Kei; Tint, Mya Thway; Aguilera, Rosana; Dickens, Borame Sue Lee; Choo, Sue; Ang, Li Ting; Phua, Desiree; Law, Evelyn C.; Ng, Sharon; Tan, Karen Mei-Ling; Benmarhnia, Tarik; Karnani, Neerja; Eriksson, Johan G.; Chong, Yap-Seng; Yap, Fabian; Tan, Kok Hian; Lee, Yung Seng; Chan, Shiao-Yng; Chong, Mary F. F.; Huang, Jonathan
Contributor organization: Clinicum
Research Programs Unit
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
University of Helsinki
Date: 2022-05
Language: eng
Number of pages: 16
Belongs to series: Environment International
ISSN: 0160-4120
DOI: https://doi.org/10.1016/j.envint.2022.107205
URI: http://hdl.handle.net/10138/345813
Abstract: Background: While socioeconomic position (SEP) is consistently related to pregnancy and birth outcome dis-parities, relevant biological mechanisms are manifold, thus necessitating more comprehensive characterization of SEP-exposome associations during pregnancy. Objectives: We implemented an exposomic approach to systematically characterize the socioeconomic landscape of prenatal exposures in a setting where social segregation was less distinct in a hypotheses-generating manner. Methods: We described the correlation structure of 134 prenatal exogenous and endogenous sources (e.g., micronutrients, hormones, immunomodulatory metabolites, environmental pollutants) collected in a diverse, population-representative, urban, high-income longitudinal mother-offspring cohort (N = 1341; 2009-2011). We examined the associations between maternal, paternal, household, and areal level SEP indicators and 134 ex-posures using multiple regressions adjusted for precision variables, as well as potential effect measure modifi-cation by ethnicity and nativity. Finally, we generated summary SEP indices using Multiple Correspondence Analysis to further explore possible curved relationships. Results: Individual and household SEP were associated with anthropometric/adiposity measures, folate, omega-3 fatty acids, insulin-like growth factor-II, fasting glucose, and neopterin, an inflammatory marker. We observed paternal education was more strongly and consistently related to maternal exposures than maternal education. This was most apparent amongst couples discordant on education. Analyses revealed additional non-linear as-sociations between areal composite SEP and particulate matter. Environmental contaminants (e.g., per-and polyfluoroalkyl substances) and micronutrients (e.g., folate and copper) showed opposing associations by ethnicity and nativity, respectively. Discussion: SEP-exposome relationships are complex, non-linear, and context specific. Our findings reinforce the potential role of paternal contributions and context-specific modifiers of associations, such as between ethnicity and maternal diet-related exposures. Despite weak presumed areal clustering of individual exposures in our context, our approach reinforces subtle non-linearities in areal-level exposures.
Subject: Exposome
Socioeconomic position
Inequality
Biomarkers
Pregnancy
AIR-POLLUTION
GROWTH-FACTORS
HEALTH
NEIGHBORHOOD
EDUCATION
ASSOCIATION
EXPOSURE
OUTCOMES
RISK
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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