Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life

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Lamichhane , S , Siljander , H , Salonen , M , Ruohtula , T , Virtanen , S M , Ilonen , J , Hyötyläinen , T , Knip , M & Oresic , M 2022 , ' Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life ' , Frontiers in nutrition , vol. 9 , 859627 . https://doi.org/10.3389/fnut.2022.859627

Title: Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life
Author: Lamichhane, Santosh; Siljander, Heli; Salonen, Marja; Ruohtula, Terhi; Virtanen, Suvi M.; Ilonen, Jorma; Hyötyläinen, Tuulia; Knip, Mikael; Oresic, Matej
Contributor organization: Clinicum
HUS Children and Adolescents
Children's Hospital
University of Helsinki
CAMM - Research Program for Clinical and Molecular Metabolism
Research Services
Date: 2022-05-24
Language: eng
Number of pages: 10
Belongs to series: Frontiers in nutrition
ISSN: 2296-861X
DOI: https://doi.org/10.3389/fnut.2022.859627
URI: http://hdl.handle.net/10138/345933
Abstract: Background: Current evidence suggests that the composition of infant formula (IF) affects the gut microbiome, intestinal function, and immune responses during infancy. However, the impact of IF on circulating lipid profiles in infants is still poorly understood. The objectives of this study were to (1) investigate how extensively hydrolyzed IF impacts serum lipidome compared to conventional formula and (2) to associate changes in circulatory lipids with gastrointestinal biomarkers including intestinal permeability. Methods: In a randomized, double-blind controlled nutritional intervention study (n = 73), we applied mass spectrometry-based lipidomics to analyze serum lipids in infants who were fed extensively hydrolyzed formula (HF) or conventional, regular formula (RF). Serum samples were collected at 3, 9, and 12 months of age. Child's growth (weight and length) and intestinal functional markers, including lactulose mannitol (LM) ratio, fecal calprotectin, and fecal beta-defensin, were also measured at given time points. At 3 months of age, stool samples were analyzed by shotgun metagenomics. Results: Concentrations of sphingomyelins were higher in the HF group as compared to the RF group. Triacylglycerols (TGs) containing saturated and monounsaturated fatty acyl chains were found in higher levels in the HF group at 3 months, but downregulated at 9 and 12 months of age. LM ratio was lower in the HF group at 9 months of age. In the RF group, the LM ratio was positively associated with ether-linked lipids. Such an association was, however, not observed in the HF group. Conclusion: Our study suggests that HF intervention changes the circulating lipidome, including those lipids previously found to be associated with progression to islet autoimmunity or overt T1D.
Subject: lipidome
early life
metabolomics
extensively hydrolyzed infant formula
intestinal permeability
lipidomics
ISLET AUTOIMMUNITY
LYSOPHOSPHATIDYLCHOLINE
METABOLISM
CHILDREN
MILK
1ST
DETERMINANTS
PREVENTION
RISK
3143 Nutrition
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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