Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study

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Niinistö , S , Miettinen , M E , Cuthbertson , D , Honkanen , J , Hakola , L , Autio , R , Erlund , I , Arohonka , P , Vuorela , A , Härkönen , T , Hyöty , H , Krischer , J P , Vaarala , O , Knip , M & Virtanen , S M 2022 , ' Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study ' , Frontiers in Immunology , vol. 13 , 858875 . https://doi.org/10.3389/fimmu.2022.858875

Title: Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study
Author: Niinistö, Sari; Miettinen, Maija E.; Cuthbertson, David; Honkanen, Jarno; Hakola, Leena; Autio, Reija; Erlund, Iris; Arohonka, Petra; Vuorela, Arja; Härkönen, Taina; Hyöty, Heikki; Krischer, Jeffrey P.; Vaarala, Outi; Knip, Mikael; Virtanen, Suvi M.
Contributor organization: HUS Children and Adolescents
CAMM - Research Program for Clinical and Molecular Metabolism
Children's Hospital
University of Helsinki
Molecular and Integrative Biosciences Research Programme
Date: 2022-05-25
Language: eng
Number of pages: 10
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2022.858875
URI: http://hdl.handle.net/10138/345935
Abstract: AimsAltered immune functions as well as fatty acid intake and status have been associated with the development of type 1 diabetes. We aimed to study the relationship between fatty acids and immunological markers in young children with increased genetic risk for type 1 diabetes in order to define putative mechanisms related to development of islet autoimmunity. MethodsSerum samples for fatty acid and immunological marker measurements were obtained in the Trial to Reduce IDDM in the Genetically at Risk (TRIGR) ancillary study (Divia) from children born between 2002 and 2007 in 15 countries. Case children (n = 95) were defined as having repeated positivity for at least two out of four diabetes-associated autoantibodies. For each case child, control children were selected matched for country and date of birth (n = 173). Serum fatty acids and immunological markers were measured from cord serum and at the age of 6 and 12 months. Spearman correlation coefficients were calculated between fatty acids and immunological markers. ResultsCorrelations between circulating fatty acids and immunological markers were different in case children who developed islet autoimmunity than in control children already at birth continuing across the first year of life. In case children, saturated fatty acids (SFAs) showed stronger correlations with immunological markers, while in controls, polyunsaturated fatty acids (PUFAs) showed stronger correlations. ConclusionsIn cases, SFAs were associated with several immunological markers (CXCL10, IL-6, IL-9, IL-17, and CM-CSF) previously linked to the type 1 diabetes disease process. Findings indicate that fatty acids could have immunomodulatory potential in the early phase of the disease development, although causality between fatty acids and the immunological pathways remains to be explored. Trial registry numberNCT00179777
Subject: fatty acids
immunological markers
cytokines
chemokines
growth factors
islet autoimmunity
children
type 1 diabetes
BETA-CELL AUTOIMMUNITY
PLASMALOGEN STATUS
TYPE-1
RISK
INFLAMMATION
IMMUNITY
INFANCY
CXCL10
LINE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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