Donor and Recipient Sex Matching and Corneal Graft Failure in High-Risk and Non-High-Risk Patients

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http://hdl.handle.net/10138/345938

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Achiron , A , Yahalomi , T , Hecht , I , Stanescu , N , Noy , R A , Burgansky-Eliash , Z , Avizemer , H , Tuuminen , R & Spierer , O 2022 , ' Donor and Recipient Sex Matching and Corneal Graft Failure in High-Risk and Non-High-Risk Patients ' , Journal of ophthalmology , vol. 2022 , 1520912 . https://doi.org/10.1155/2022/1520912

Title: Donor and Recipient Sex Matching and Corneal Graft Failure in High-Risk and Non-High-Risk Patients
Author: Achiron, Asaf; Yahalomi, Tal; Hecht, Idan; Stanescu, Nir; Noy, Romi Achiron; Burgansky-Eliash, Zvia; Avizemer, Haggai; Tuuminen, Raimo; Spierer, Oriel
Contributor organization: Clinicum
HUS Head and Neck Center
University of Helsinki
Silmäklinikka
Kymsote – Social and Health Services in Kymenlaakso
HYKS erva
Date: 2022-04-16
Language: eng
Number of pages: 6
Belongs to series: Journal of ophthalmology
ISSN: 2090-004X
DOI: https://doi.org/10.1155/2022/1520912
URI: http://hdl.handle.net/10138/345938
Abstract: Purpose. It is controversial whether donor-recipient sex mismatch is a risk factor associated with corneal graft failure. The purpose of this study was to investigate the effect of sex mismatch on corneal graft failure in high-risk and non-high-risk patients. Design. A retrospective study. Methods. The medical charts of patients who underwent corneal transplantations by one surgeon between 2012 and 2017 were reviewed. Patients were defined as high-risk for failure if they had glaucoma, ocular surface disease, or corneal vascularization. Graft failure rates were compared using the Kaplan-Meier survival curves between sex matched and mismatched subjects and between male-to-female grafting and other patients. Results. One hundred and thirteen patients with a minimum follow-up of 18 months were included. In 62 non-high-risk patients, graft failure rates were similar between the sex mismatched and the sex matched recipients (p=0.645, log-rank) and in male donor to female recipient transplantations and in the other transplantations (p=0.496, log-rank). Analysis of fifty-one eyes of 51 high-risk graft recipients (mean age of 73.4 +/- 12.7 years, N = 26 females) showed that graft failure rates were significantly higher in the sex mismatched than sex matched recipients (p=0.022, log-rank) and in male donor to female recipient transplantations than in the other transplantations (p=0.002, log-rank). Conclusions. Sex matching for every patient bares logistic difficulties; however, in patients who are at high-risk for graft failure, it may be a simple way to improve outcomes and better utilize corneal grafts.
Subject: ANTERIOR LAMELLAR KERATOPLASTY
H-Y
PENETRATING KERATOPLASTY
ALLOGRAFT-REJECTION
ANTIGEN
TRANSPLANTATION
SURVIVAL
IMPACT
DSAEK
3125 Otorhinolaryngology, ophthalmology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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