A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals : The deAGEing Trial

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Linkens , A M A , van Best , N , Niessen , P M , Wijckmans , N E G , de Goei , E E C , Scheijen , J L J M , van Dongen , M C J M , van Gool , C C J A W , de Vos , W M , Houben , A J H M , Stehouwer , C D A , Eussen , S J M P , Penders , J & Schalkwijk , C G 2022 , ' A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals : The deAGEing Trial ' , International Journal of Molecular Sciences , vol. 23 , no. 10 , 5328 . https://doi.org/10.3390/ijms23105328

Title: A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals : The deAGEing Trial
Author: Linkens, Armand M. A.; van Best, Niels; Niessen, Petra M.; Wijckmans, Nicole E. G.; de Goei, Erica E. C.; Scheijen, Jean L. J. M.; van Dongen, Martien C. J. M.; van Gool, Christel C. J. A. W.; de Vos, Willem M.; Houben, Alfons J. H. M.; Stehouwer, Coen D. A.; Eussen, Simone J. M. P.; Penders, John; Schalkwijk, Casper G.
Contributor organization: Willem Meindert Vos de / Principal Investigator
de Vos & Salonen group
University of Helsinki
HUMI - Human Microbiome Research
Faculty of Medicine
Date: 2022-05
Language: eng
Number of pages: 16
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms23105328
URI: http://hdl.handle.net/10138/345939
Abstract: Dietary advanced glycation endproducts (AGEs), abundantly present in Westernized diets, are linked to negative health outcomes, but their impact on the gut microbiota has not yet been well investigated in humans. We investigated the effects of a 4-week isocaloric and macronutrient-matched diet low or high in AGEs on the gut microbial composition of 70 abdominally obese individuals in a double-blind parallel-design randomized controlled trial (NCT03866343). Additionally, we investigated the cross-sectional associations between the habitual intake of dietary dicarbonyls, reactive precursors to AGEs, and the gut microbial composition, as assessed by 16S rRNA amplicon-based sequencing. Despite a marked percentage difference in AGE intake, we observed no differences in microbial richness and the general community structure. Only the Anaerostipes spp. had a relative abundance >0.5% and showed differential abundance (0.5 versus 1.11%; p = 0.028, after low- or high-AGE diet, respectively). While the habitual intake of dicarbonyls was not associated with microbial richness or a general community structure, the intake of 3-deoxyglucosone was especially associated with an abundance of several genera. Thus, a 4-week diet low or high in AGEs has a limited impact on the gut microbial composition of abdominally obese humans, paralleling its previously observed limited biological consequences. The effects of dietary dicarbonyls on the gut microbiota composition deserve further investigation.
Subject: dietary advanced glycation end products
dietary dicarbonyls
UPLC-MS
MS
RCT
gut microbiota
16S rRNA
alpha diversity
beta diversity
differential abundance
INSULIN SENSITIVITY
MAILLARD REACTION
END-PRODUCTS
FOOD
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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