Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events

Show simple item record Tanabe, Shihori O'Brien, Jason Tollefsen, Knut Erik Kim, Young Jun Chauhan, Vinita Yauk, Carole Huliganga, Elizabeth Rudel, Ruthann Kay, Jennifer Helm, Jessica Beaton, Danielle Filipovska, Julija Sovadinova, Iva Garcia-Reyero, Natalia Mally, Angela Poulsen, Sarah Søs Delrue, Nathalie Fritsche, Ellen Luettich, Karsta La Rocca, Cinzia Yepiskoposyan, Hasmik Klose, Jördis Danielsen, Pernille Høgh Esterhuizen, Maranda Jacobsen, Nicklas Raun Vogel, Ulla Gant, Timothy Choi, Ian FitzGerald, Rex 2022-07-07T05:32:02Z 2022-07-07T05:32:02Z 2022-07-06
dc.identifier.citation Tanabe , S , O'Brien , J , Tollefsen , K E , Kim , Y J , Chauhan , V , Yauk , C , Huliganga , E , Rudel , R , Kay , J , Helm , J , Beaton , D , Filipovska , J , Sovadinova , I , Garcia-Reyero , N , Mally , A , Poulsen , S S , Delrue , N , Fritsche , E , Luettich , K , La Rocca , C , Yepiskoposyan , H , Klose , J , Danielsen , P H , Esterhuizen , M , Jacobsen , N R , Vogel , U , Gant , T , Choi , I & FitzGerald , R 2022 , ' Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events ' , Frontiers in Toxicology , vol. 4 .
dc.identifier.other PURE: 215952095
dc.identifier.other PURE UUID: 273366be-408d-42f6-bea8-3ec8cd83c752
dc.identifier.other ORCID: /0000-0002-2342-3941/work/115596190
dc.description.abstract Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stressors. The action of ROS and RNS, collectively referred to as reactive oxygen and nitrogen species (RONS), has recently become highly relevant in a number of adverse outcome pathways (AOPs) that capture, organize, evaluate and portray causal relationships pertinent to adversity or disease progression. RONS can potentially act as a key event (KE) in the cascade of responses leading to an adverse outcome (AO) within such AOPs, but are also known to modulate responses of events along the AOP continuum without being an AOP event itself. A substantial discussion has therefore been undertaken in a series of workshops named “Mystery or ROS” to elucidate the role of RONS in disease and adverse effects associated with exposure to stressors such as nanoparticles, chemical, and ionizing and non-ionizing radiation. This review introduces the background for RONS production, reflects on the direct and indirect effects of RONS, addresses the diversity of terminology used in different fields of research, and provides guidance for developing a harmonized approach for defining a common event terminology within the AOP developer community. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Frontiers in Toxicology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 1181 Ecology, evolutionary biology
dc.title Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events en
dc.type Review Article
dc.contributor.organization Ecosystems and Environment Research Programme
dc.contributor.organization Helsinki Institute of Sustainability Science (HELSUS)
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2673-3080
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
54._Tanabi_ROS_Review.pdf 1.000Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record