Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events

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dc.contributor.author Tanabe, Shihori
dc.contributor.author O'Brien, Jason
dc.contributor.author Tollefsen, Knut Erik
dc.contributor.author Kim, Young Jun
dc.contributor.author Chauhan, Vinita
dc.contributor.author Yauk, Carole
dc.contributor.author Huliganga, Elizabeth
dc.contributor.author Rudel, Ruthann
dc.contributor.author Kay, Jennifer
dc.contributor.author Helm, Jessica
dc.contributor.author Beaton, Danielle
dc.contributor.author Filipovska, Julija
dc.contributor.author Sovadinova, Iva
dc.contributor.author Garcia-Reyero, Natalia
dc.contributor.author Mally, Angela
dc.contributor.author Poulsen, Sarah Søs
dc.contributor.author Delrue, Nathalie
dc.contributor.author Fritsche, Ellen
dc.contributor.author Luettich, Karsta
dc.contributor.author La Rocca, Cinzia
dc.contributor.author Yepiskoposyan, Hasmik
dc.contributor.author Klose, Jördis
dc.contributor.author Danielsen, Pernille Høgh
dc.contributor.author Esterhuizen, Maranda
dc.contributor.author Jacobsen, Nicklas Raun
dc.contributor.author Vogel, Ulla
dc.contributor.author Gant, Timothy
dc.contributor.author Choi, Ian
dc.contributor.author FitzGerald, Rex
dc.date.accessioned 2022-07-07T05:32:02Z
dc.date.available 2022-07-07T05:32:02Z
dc.date.issued 2022-07-06
dc.identifier.citation Tanabe , S , O'Brien , J , Tollefsen , K E , Kim , Y J , Chauhan , V , Yauk , C , Huliganga , E , Rudel , R , Kay , J , Helm , J , Beaton , D , Filipovska , J , Sovadinova , I , Garcia-Reyero , N , Mally , A , Poulsen , S S , Delrue , N , Fritsche , E , Luettich , K , La Rocca , C , Yepiskoposyan , H , Klose , J , Danielsen , P H , Esterhuizen , M , Jacobsen , N R , Vogel , U , Gant , T , Choi , I & FitzGerald , R 2022 , ' Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events ' , Frontiers in Toxicology , vol. 4 . https://doi.org/10.3389/ftox.2022.887135
dc.identifier.other PURE: 215952095
dc.identifier.other PURE UUID: 273366be-408d-42f6-bea8-3ec8cd83c752
dc.identifier.other ORCID: /0000-0002-2342-3941/work/115596190
dc.identifier.uri http://hdl.handle.net/10138/345960
dc.description.abstract Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stressors. The action of ROS and RNS, collectively referred to as reactive oxygen and nitrogen species (RONS), has recently become highly relevant in a number of adverse outcome pathways (AOPs) that capture, organize, evaluate and portray causal relationships pertinent to adversity or disease progression. RONS can potentially act as a key event (KE) in the cascade of responses leading to an adverse outcome (AO) within such AOPs, but are also known to modulate responses of events along the AOP continuum without being an AOP event itself. A substantial discussion has therefore been undertaken in a series of workshops named “Mystery or ROS” to elucidate the role of RONS in disease and adverse effects associated with exposure to stressors such as nanoparticles, chemical, and ionizing and non-ionizing radiation. This review introduces the background for RONS production, reflects on the direct and indirect effects of RONS, addresses the diversity of terminology used in different fields of research, and provides guidance for developing a harmonized approach for defining a common event terminology within the AOP developer community. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Frontiers in Toxicology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 1181 Ecology, evolutionary biology
dc.title Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events en
dc.type Review Article
dc.contributor.organization Ecosystems and Environment Research Programme
dc.contributor.organization Helsinki Institute of Sustainability Science (HELSUS)
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/ftox.2022.887135
dc.relation.issn 2673-3080
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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