Case Report : Supernormal Vascular Aging in Leningrad Siege Survivors

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Rotar , O , Boyarinova , M , Moguchaya , E , Tolkunova , K , Kolosov , N , Rezapova , V , Freylikhman , O , Usoltsev , D , Melnik , O , Sergushichev , A , Solntsev , V , Kostareva , A , Dubinina , E , Voortman , T , Stevens , C , Daly , M J , Konradi , A , Shlyakhto , E & Artomov , M 2022 , ' Case Report : Supernormal Vascular Aging in Leningrad Siege Survivors ' , Frontiers in cardiovascular medicine , vol. 9 , 843439 .

Title: Case Report : Supernormal Vascular Aging in Leningrad Siege Survivors
Author: Rotar, Oxana; Boyarinova, Maria; Moguchaya, Ekaterina; Tolkunova, Kristina; Kolosov, Nikita; Rezapova, Valeriia; Freylikhman, Olga; Usoltsev, Dmitrii; Melnik, Olesya; Sergushichev, Alexey; Solntsev, Vladislav; Kostareva, Anna; Dubinina, Elena; Voortman, Trudy; Stevens, Christine; Daly, Mark J.; Konradi, Alexandra; Shlyakhto, Evgeny; Artomov, Mykyta
Contributor organization: Institute for Molecular Medicine Finland
Date: 2022-05-23
Language: eng
Number of pages: 6
Belongs to series: Frontiers in cardiovascular medicine
ISSN: 2297-055X
Abstract: Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.
Subject: supernormal vascular aging
deep phenotyping
pulse wave velocity (PWV)
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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